Therapeutic Implications of Early Transesophageal Echocardiography in Embolic Stroke of Undetermined Source (ESUS)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 186
- 试验地点
- 1
- 主要终点
- therapeutic modification after transesophageal echocardiography
研究概览
简要总结
The ESUS concept was introduced recently to describe a non-lacunar stroke of undetermined etiology. The following etiological workup is required in this setting: head CT or MRI, 12-lead ECG, transthoracic echocardiography, continuous cardiac monitoring for at least 24 hours after stroke, vascular imaging (ultrasound, magnetic resonance angiography, CT angiography, catheter angiography). Transesophageal echocardiography (TEE) is considered not to be required.
However, aortic arch atheroma as diagnosed by TEE in the setting of recent ischemic stroke is a major aortic source of embolism, as supported by numerous well conducted studies. The European Association of Echocardiography considers that TEE is the gold standard for the diagnosis and the characterization of aortic atheroma. It is also the method of choice for the diagnosis of infectious endocarditis.
The aim of this work was to evaluate the rate of patients with a therapeutic modification induced by TEE (mainly anticoagulation and surgery), in consecutive patients admitted with ESUS at our institution stroke unit.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Presenting with a new onset of ischemic stroke
- •Meeting the ESUS criteria (Embolic Stroke of Undetermined Source)
- •Comprehensive transthoracic echo prior to the TEE
排除标准
- •ESUS criteria not met
- •Contraindications to TEE
- •TEE failure
- •Pregnant or breastfeeding woman
- •Person under legal protection
- •No medical insurance coverage
结局指标
主要结局
therapeutic modification after transesophageal echocardiography
时间窗: 24 hours after TEE
proportion of patients with a therapeutic modification (mainly anticoagulation and surgery)
次要结局
未报告次要终点