Transcranial Direct Current Stimulation in the Visual Cortex of Migraine Patients: Neurophysiological and Clinical Implications
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Migraine
- Sponsor
- Universidade Federal de Pernambuco
- Enrollment
- 36
- Locations
- 1
- Primary Endpoint
- Change from phosphene threshold
- Last Updated
- 11 years ago
Overview
Brief Summary
Migraine has been described as one of the most common neurological diseases, with high social and economic impact. Despite the high prevalence, the pathophysiology of migraine is still unknown, several studies have been developed in order to advance the understanding of the pathophysiological mechanisms of the disease which are not yet entirely elucidated. The aim of this study is to observe the effects of transcranial direct current stimulation (tDCS), applied in the visual cortex, on neurophysiological and clinical measures (frequency, intensity, duration of attacks and severity of pain) in migraine patients.
Investigators
Kátia Monte-Silva
Professor
Universidade Federal de Pernambuco
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Change from phosphene threshold
Time Frame: At baseline,1 month, 2 months, 3 months/ per session - at baseline and 30 minutes (after tDCS)
A 10-cm circular coil was used that has giving a peak magnetic field strength of 2 tesla. Subjects were asked to wear a blindfold, sit comfortably in a chair and to close their eyes to diminish ambient light.In sagittal line, three points were scored: 2, 3 and 4 cm above the inion. The single pulse transcranial magnetic stimulation was applied to one of the points scored and the subject was asked to report the presence or absence of a phosphene immediately after stimulation. The stimulation was repeated ten times at each intensity with a maximum frequency of 0.2 Hz, stimulation was initially applied to 60% of the maximum intensity of the stimulator. The intensity of stimulation was changed into blocks of 5% to minimum intensity that the subject can perceive the phosphene certainly, five times ten, then this value was set as the PT for migraineurs and controls.
Secondary Outcomes
- Change from eletroencephalography(At baseline, 1 month and 2 months, 3 months)
- Change from pain diary(3 followed months)