CXCL9, CXCL10, CXCL11, and CXCR3 in Dry Eye Syndrome

Completed

• Conditions: Dry Eye Syndrome

• Registration Number: NCT00991679
• Lead Sponsor: Chonnam National University Hospital

Brief Summary

The aim of this study is to investigate the expression of CXCL9, CXCL10, CXCL11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome.

Thirty-three patients with dry eye (16 Sjögren's syndrome and 17 non-Sjögren's syndrome patients) and 15 control subjects were recruited. The concentrations of CXCL9, CXCL10, and CXCL11 in tears were measured using enzyme-linked immunosorbent assay. The correlation between chemokine levels and tear film and ocular surface parameters was analyzed. Expression of CXCL9, CXCL10, CXCL11, and CXCR3 in the conjunctiva was evaluated using immunohistochemistry. Flow cytometry was performed to count CXCR3+ cells and CXCR3+CD4+ cells in the conjunctiva.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-02
• Primary Completion: 2008-10
• Study Completion: 2008-12
• Status Verified: 2009-10
• Study First Submitted: 2009-10-07
• Study First Submitted QC: 2009-10-07
• Last Update Submitted: 2009-10-07
• Study First Posted: 2009-10-08
• Last Update Posted: 2009-10-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

• clinical diagnosis of dry eye syndrome

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Exclusion Criteria

• active ocular infection or inflammation not associated with dry eye
• drug toxicity
• contact lens wear
• ocular allergy
• ocular surgery within the last 3 months
• lid or lash abnormalities

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Chonnam National University Hospital; 🇰🇷 Gwangju, Chonnam, Korea, Republic of