Prospective study for postoperative motor and cognitive improvement by maintaining mild hypercapnia during general anesthesia
Not Applicable
- Conditions
- Patients undergoing open abdominal surgery under general anesthesia
- Registration Number
- JPRN-UMIN000043793
- Lead Sponsor
- Chiba university
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
Not provided
Exclusion Criteria
1. Laparoscopic surgery patients 2. Patients with pulmonary hypertension 3. Obstructive lung disease 4. Patients with congenital heart disease 5. Patients with high intracranial pressure 6.Patients with other pathological conditions exacerbated by hypercapnia 7.Patients who used benzodiazepines the day before or during surgery 8.Patients diagnosed with cognitive dysfunction before surgery 9.Patients with difficult epidural insertion 10.Patients whose grip strength measurement is difficult due to physical reasons 11.Emergency surgery 12.State with data loss 13.Patients judged by the principal investigator to be inappropriate as subjects
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Grip strength fluctuation rate on the 7th day after surgery (grip strength on the 7th day after surgery / preoperative grip strength)
- Secondary Outcome Measures
Name Time Method Grip strength the day after surgery, incidence of delirium, MMSE score 7 days after surgery