Reducing renal function deterioration by means of increasing medication adherence, improving immunosuppressive drug exposure and supporting a healthy lifestyle - an implementation study.

Completed

• Conditions: graft function; Kidney transplantation; 10038430

• Registration Number: NL-OMON50600
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

- > 1 year after kidney transplantation
- Follow-up visits take place in LUMC
- Creatinine clearance (CKD-EPI > 25 ml/min)
- Immunosuppressive regimen based on tacrolimus
- Sufficient mastery of Dutch
- Access to and capacity to use the internet.
- Availability of a Smart-phone (necessary for blistering)
- Informed consent

Exclusion Criteria

- No internet access
- Creatinine clearance (CKD-EPI * 25 ml/min)
- Insufficient knowledge of Dutch language
- Proven allergy for iodine contrast

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study parameter is reduction in renal function deterioration. Renal<br /><br>function will be determined using iohexol measurement. Iohexol will be injected<br /><br>in the vene of the patient according to the routine clinical protocol,<br /><br>subsequently blood drawing will take place at (3 or 4) preset time points.<br /><br>Concentrations will be measured using HPLC technique at the laboratory. Using<br /><br>the blood concentrations in a pre-developed limited sampling model, an area<br /><br>under the concentration time curve will be determined. Subsequently the GFR is<br /><br>calculated. This procedure is performed at study start and study end. The GFR<br /><br>decline will then be calculated based on these two measurement for all<br /><br>patients. </p><br>