RANDOMIZED CONTROLLED TRIAL TO COMPARE THE POST-OPERATIVE PAIN AND RECOVERY CHARACTERISTICS USING CONVENTIONAL OPIOID BASED VERSUS OPIOID FREE ANAESTHESIA FOR LAPAROSCOPIC CHOLECYSTECTOMY

Currently, there is a paucity of randomized controlled trials that directly compare the efficacy of

conventional opioid-based anaesthesia with OFA incorporating laparoscopic TAP blocks during

laparoscopic cholecystectomy in terms of postoperative pain control, recovery metrics, opioid

consumption, PONV, and patient satisfaction.

Therefore, this study is being done to contribute supportive evidence to the existing literature on

whether an opioid free anaesthesia approach incorporating laparoscopic-guided TAP block

provides superior postoperative outcomes compared to the conventional opioid based anesthesia

in laparoscopic cholecystectomy.

Study area:

The study will be conducted in the operation theatre complex, Department of

Anaesthesiology & Critical care at Dr. Baba Saheb Ambedkar Medical college and

Hospital, Sector-6, Rohini, Delhi.

Primary Objective:

Comparing post-operative pain using opioid free anesthesia (intravenous dexmedetomidine ,

ketamine and laparoscopic guided transversus abdominis plane block) versus conventional

opioid based anesthesia for laparoscopic cholecystectomy using –

a) Visual Analogue Scale (VAS) every 4 hour till 24 hours

b) Total amount of analgesic requirement in 24 hours

Secondary Objectives:

Compare both groups regarding:

1. Time taken for extubation

2. Post-operative sedation score (Modified Ramsay Sedation Scale)

3. Incidence of PONV (Verbal Rating Scale)

4. Patient satisfaction (QoR-15 Scale)