EFFECT OF NON SURGICAL PERIODONTAL THERAPY ON GHRELIN AND TUMOR NECROSIS FACTOR -ALPHA (TNF-a) IN GINGIVAL CERVICULAR FLUID OF HEALTH AND CHROINC GENERALISED PERIODONTITIS WITH AND WITHOUT TYPE 2 DIABETES MELLITUS -A - CLINICO-BIOCHEMICAL STUDY
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- levels of Ghrelin and TNF- alpha in GCF after NSPT
研究概览
简要总结
Periodontitis is a chronic inflammatory disease that leads to irreversible damage and tooth loss. Ghrelin a peptide hormone , plays a key role in periodontal health by modulating inflammatory responses. TNF-alpha , a pro inflammatory cytokine, contribute to insulin resistance and T2DM. Reduced expression of ghrelin receptors in periodntal tissue may enhance TNF-alpha activity, leading to inflammation. This study mains to estimate and compare ghrelin and TNF alpha levels in GCF before and after NSPT in healthy, periodontitis with and without T2DM individuals. the objective of the study is to estimate the ghrelin and TNF- alpha in healthy , periodontitis with and without T2DM individuals before and after NSPT and to assess the potential of ghrelin as an inflammatory markers in period0ntitis
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 20.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1.age between 20 to 60 2.indivigual in which there is presence of at least 20 natural teeth 3.patients with Stage III grade B periodontitis.
- •4.Patients with healthy periodontium 5.sumjects with controlled T2DM
- •Subjects without T2DM.
排除标准
- •1.individuals with other systemic disease other than controlled T2DM 2.Individuals who have received periodontal therapy in the last 6 months.
- •3.smokers 4.Pregnant/lactating mothers 5.individuals who had antimicrobial and Anti-inflammatory therapy in last 6 months.
结局指标
主要结局
levels of Ghrelin and TNF- alpha in GCF after NSPT
时间窗: baseline and end of 3 months after NSPT
次要结局
- Plaque index , Gingival Index Bleeding on probing Probing Depth and clinical attachment loss(baseline and end of 3 months after NSPT)
研究者
Kaustubh Ram
The Oxford Dental College, Bangalore