Prospective Cohort Study on Prognosis of Patients With Hepatitis B/C in Hainan Province Danzhou City
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60,000
- 主要终点
- Long-term outcome
研究概览
简要总结
Hepatitis B (HBV) and hepatitis C (HCV) are prevalent all over the world, which seriously threatens public health. In 2016, the World Health Organization(WHO) put forward the goal of eliminating the threat of viral hepatitis to public health by 2030. However, at present, the diagnosis rate and treatment rate of chronic HBV and HCV in China are still far from the goal put forward by WHO. Therefore, for China, the elimination of viral hepatitis is still a public health problem that needs a long time to face.
This study aims to screen and follow up HBV and HCV patients in Danzhou City, Hainan Province, so as to understand the epidemiological characteristics and long-term prognosis of HBV/HCV patients.
详细描述
Hepatitis B (HBV) and hepatitis C (HCV) are prevalent all over the world, which seriously threatens public health. According to the survey, there are about 93 million chronic HBV infected people and 10 million chronic HCV infected people in China, accounting for 36.19% and 14.08% of the global HBV and HCV infected people respectively. Chronic HBV and HCV infection is the main cause of liver cirrhosis and liver cancer, which places a great burden on the national economy.
In 2016, the World Health Organization(WHO) put forward the goal of eliminating the threat of viral hepatitis to public health by 2030, including 90% diagnosis rate, 80% treatment rate and 90% cure rate of viral hepatitis, in order to reduce 65% of viral hepatitis related deaths and reduce the disease burden. However, at present, the diagnosis rate of chronic HBV in China is 18.7%, the treatment rate is 10.8%, the diagnosis rate of chronic HCV is 30%, and the treatment rate is 9%, which are still far from the goal put forward by WHO. Therefore, for China, the elimination of viral hepatitis is still a public health problem that needs a long time to face.
This study aims to screen and follow up HBV and HCV patients in Danzhou City, Hainan Province, so as to understand the epidemiological characteristics and long-term prognosis of HBV/HCV patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •HBsAg/HBV DNA positive
- •or anti-HCV/HCV RNA positive
排除标准
- •patients who refused to participate in the study.
结局指标
主要结局
Long-term outcome
时间窗: up to 192 weeks
Long-term outcome of HBV/HCV infected patients in Danzhou City, Hainan Province
Risk factors
时间窗: up to 192 weeks
Risk factors for long-term outcome of HBV/HCV infected patients in Danzhou City, Hainan Province
Epidemiological characteristics of hepatitis B and C
时间窗: up to 192 weeks
Epidemiological characteristics of hepatitis B and C in Danzhou City, Hainan Province
次要结局
- Hepatic decompensation(up to 192 weeks)
- Survival rate for cirrhosis(up to 192 weeks)
- Incidence of cirrhosis(up to 192 weeks)
- Incidence of liver cancer(up to 192 weeks)
- HBV interruption rate of perinatal transmission(up to 192 weeks)
- HBsAg loss(up to 192 weeks)
- Survival rate for liver cancer(up to 192 weeks)
研究者
Lin Bingliang
Professor
Sun Yat-sen University
