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临床试验/NCT05102838
NCT05102838尚未招募不适用

Prospective Cohort Study on Prognosis of Patients With Hepatitis B/C in Hainan Province Danzhou City

Sun Yat-sen University0 个研究点目标入组 60,000 人开始时间: 2021年11月1日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
60,000
主要终点
Long-term outcome

研究概览

简要总结

Hepatitis B (HBV) and hepatitis C (HCV) are prevalent all over the world, which seriously threatens public health. In 2016, the World Health Organization(WHO) put forward the goal of eliminating the threat of viral hepatitis to public health by 2030. However, at present, the diagnosis rate and treatment rate of chronic HBV and HCV in China are still far from the goal put forward by WHO. Therefore, for China, the elimination of viral hepatitis is still a public health problem that needs a long time to face.

This study aims to screen and follow up HBV and HCV patients in Danzhou City, Hainan Province, so as to understand the epidemiological characteristics and long-term prognosis of HBV/HCV patients.

详细描述

Hepatitis B (HBV) and hepatitis C (HCV) are prevalent all over the world, which seriously threatens public health. According to the survey, there are about 93 million chronic HBV infected people and 10 million chronic HCV infected people in China, accounting for 36.19% and 14.08% of the global HBV and HCV infected people respectively. Chronic HBV and HCV infection is the main cause of liver cirrhosis and liver cancer, which places a great burden on the national economy.

In 2016, the World Health Organization(WHO) put forward the goal of eliminating the threat of viral hepatitis to public health by 2030, including 90% diagnosis rate, 80% treatment rate and 90% cure rate of viral hepatitis, in order to reduce 65% of viral hepatitis related deaths and reduce the disease burden. However, at present, the diagnosis rate of chronic HBV in China is 18.7%, the treatment rate is 10.8%, the diagnosis rate of chronic HCV is 30%, and the treatment rate is 9%, which are still far from the goal put forward by WHO. Therefore, for China, the elimination of viral hepatitis is still a public health problem that needs a long time to face.

This study aims to screen and follow up HBV and HCV patients in Danzhou City, Hainan Province, so as to understand the epidemiological characteristics and long-term prognosis of HBV/HCV patients.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

性别
All
接受健康志愿者

入选标准

  • HBsAg/HBV DNA positive
  • or anti-HCV/HCV RNA positive

排除标准

  • patients who refused to participate in the study.

结局指标

主要结局

Long-term outcome

时间窗: up to 192 weeks

Long-term outcome of HBV/HCV infected patients in Danzhou City, Hainan Province

Risk factors

时间窗: up to 192 weeks

Risk factors for long-term outcome of HBV/HCV infected patients in Danzhou City, Hainan Province

Epidemiological characteristics of hepatitis B and C

时间窗: up to 192 weeks

Epidemiological characteristics of hepatitis B and C in Danzhou City, Hainan Province

次要结局

  • Hepatic decompensation(up to 192 weeks)
  • Survival rate for cirrhosis(up to 192 weeks)
  • Incidence of cirrhosis(up to 192 weeks)
  • Incidence of liver cancer(up to 192 weeks)
  • HBV interruption rate of perinatal transmission(up to 192 weeks)
  • HBsAg loss(up to 192 weeks)
  • Survival rate for liver cancer(up to 192 weeks)

研究者

发起方
Sun Yat-sen University
申办方类型
Other
责任方
Principal Investigator
主要研究者

Lin Bingliang

Professor

Sun Yat-sen University

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