To know the bettertreatment for melasma skin disease intralesional tranexamic acid or glycolic acid chemical peel

Phase 4

Not yet recruiting

Conditions: Diseases of the skin and subcutaneous tissue, (2) ICD-10 Condition: L00-L99||Diseases of the skin and subcutaneous tissue,

Registration Number: CTRI/2023/09/057178

Lead Sponsor: Madeshwari M

Brief Summary: Melasma is a common acquired hyperpigmentation disorder, various treatment modalities are available

Management is difficult because it’s frequent relapse.

Recently studies shows intralesional tranexamic acid a hemostatic agent,has hypopigmentary effect on melasma lesions

Hence, my aim of study is to compare safety and efficacy of intralesional tranexamic acid versus 50%glycolic acid chemical peel

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 40

Inclusion Criteria

Patients willing to participate in the study.

Exclusion Criteria

Before starting the study Pregnant & lactating mothers Patients on oral contraceptive pills, hormonal replacement therapy Active infection /inflammationPhotosensitivity disorders (SLE, porphyria) History of bleeding disorder /Anticoagulant treatment History of allergy Any other mode of treatment for melasma prior to the study During the Study: Develops side effects during the treatment patient wants to discontinue the treatment.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the resolution of hyperpigmentation	Baseline,week 4, week 8, week 12 and week 24

Secondary Outcome Measures

Name	Time	Method
To assess modified MASI score	Baseline, week 12 and week 24

Trial Locations

Locations (1): Chengalpattu medical College and hospital
🇮🇳
Kancheepuram, TAMIL NADU, India
Chengalpattu medical College and hospital
🇮🇳Kancheepuram, TAMIL NADU, India
DrMadeshwari M
Principal investigator
9566390496
murugeshmadhu7@gmail.com