The role of zinc supplementation in neonatal sepsis
- Conditions
- eonatal sepsis.Other sepsis
- Registration Number
- IRCT20200810048347N1
- Lead Sponsor
- Technology and Research Vice-chancellery, Hormozgan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
Presence of at least 2 clinical signs of sepsis including pallor or generalized jaundice, cardiovascular manifestations (tachy- or bradycardia, poor perfusion, or shock), change in body temperature (hypo- or hyperthermia), respiratory manifestations (grunting, intercostal retraction, apnea, or cyanosis), neurologic manifestations (hypotonia, lethargy, irritability, or seizure), gastrointestinal symptoms (abdominal distension, hepatosplenomegaly)
CRP >5 mg/ml
Presence of at least 1 positive serum parameter based on Fanarrof (book) including WBC <5000/microliter or >25000 at birth or WBC>30000 12-24 hours after birth or WBC>21000 on the second day of birth or the following days, absolute neutrophil count (ANC) <1800/microliter, platelet count <150000/microliter, immature/total (I/T) neutrophil ratio <0.16 on the first day and <0.13 from the second day on.
Gestational age >37 weeks
Age <28 days
Informed consent of the parents
Important congenital anomalies such as trisomies
Hypoxic ischemic encephalopathy
Intracranial hemorrhage
Respiratory distress syndrome
Inborn errors of metabolism
Candidiasis
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mortality. Timepoint: At the end of the study. Method of measurement: Based on patient's medical chart.
- Secondary Outcome Measures
Name Time Method Time to improvement of clinical symptoms. Timepoint: At the end of the study. Method of measurement: Daily clinical examination.;Hospital length of stay. Timepoint: At the end of the study. Method of measurement: Based on the patient's clinical charts.