Comparative Prevalence of Psychiatric Manifestations in Purely Obstetrical Antiphospholipid Syndrome
- Conditions
- Antiphospholipid Syndrome
- Interventions
- Biological: Antiphospholipid antibody testsBiological: Thrombophilia bloodworkOther: Psychiatric evaluation
- Registration Number
- NCT01649479
- Lead Sponsor
- Centre Hospitalier Universitaire de Nīmes
- Brief Summary
The main objective of this study is to estimate the lifetime prevalence of major psychiatric disorders (axis I DSM-IV; Diagnostic and Statistical Manual of Mental Disorders, version IV) in a large sample of patients with developed clinical signs of pure obstetrical antiphospholipid syndrome (suspected APS).
- Detailed Description
The secondary objectives of this study are:
A. To compare the lifetime prevalence of these major disorders between groups;
B. To assess the association of different, targeted, qualitative biomarkers with clinical symptomatology;
C. To assess the association between the presence of "transitory APS" and the presence of psychiatric disorders;
D. Estimate and compare the current prevalence (= the day of assessment) of major psychiatric disorders in the sample of patients who developed clinical signs of obstetrical APS;
E. Estimate the current prevalence (= the day of assessment) and intensity of major depressive episodes (MDE) in the sample of patients;
F. Compare the prevalence of current MDE and the intensity of depressive symptoms present between groups;
G. Estimate and compare the (lifetime and current) prevalence by category of psychiatric disorders (psychotic, anxiety, mood, etc..) in the APS group with that in the thrombophilic group and the remaining group;
H. To study the average age of onset of psychiatric disorders and clinical manifestations of APS in the sample of patients who developed clinical signs of obstetrical APS;
I. Compare the mean ages between groups;
J. Compare the mean age at onset of psychiatric disorders with the average age of the first clinical manifestation of the disease in the group of women with APS.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- Female
- Target Recruitment
- 20
- The patient must have given his/her informed and signed consent
- The patient must be insured or beneficiary of a health insurance plan
- Not postmenopausal
- Able to understand the nature, purpose and methodology of the study and agreed to cooperate in clinical and biological assessments
- Available for 12 weeks of follow-up
- Isolated obstetric morbidity, defined by at least one of the following criteria:
- at least three consecutive episodes of unexplained, early, embryonic miscarriage, which occurred before the 10th week of pregnancy, with normal maternal anatomic and hormonal assessment, normal karyotypes for both biological parents;
- at least one unexplained fetal death, defined as occurring after the 10th week of pregnancy, involving a morphologically normal fetus as documented by ultrasound examination or direct examination of the conceptus;
- at least one premature birth of a morphologically normal fetus before the 34th week of pregnancy, because of: (1) pre-eclampsia, severe or not, according to the American College of Obstetrics and Gynecology, ACOG, 2002; (2)documented placental insufficiency, defined by the following parameters: (2a) abnormal or non-reassuring fetal monitoring exam, in general a non-reactive absence-of-fetal-stress test (fetal monitoring), suggesting fetal hypoxemia; (2b) a Doppler examination of uterine arteries suggesting fetal hypoxemia, ie the absence of end-diastolic flow in the umbilical arteries; (2c) oligohydramnios, that is to say, an amniotic flow index <5 cm; (2d) indexed birth weight for gestational age and sex below the 10th percentile.
- Patient willing to accept psychological and medical care over the long term
- The patient is participating in another study
- The patient is in an exclusion period determined by a previous study
- The patient is under judicial protection, under tutorship or curatorship
- The patient refuses to sign the consent
- It is impossible to correctly inform the patient
- The patient is pregnant, parturient or breastfeeding
- Systemic vascular morbidity, defined by the following criteria: (1) Any personal history of venous thromboembolism, defined by the occurrence of deep phlebitis and / or a pulmonary embolism, diagnosed by means of objective exploration ; (2)Any personal history of superficial venous thrombosis; (3) Any personal history of clinical, symptomatic relapses of arterial insufficiency - the latter may be cerebro vascular in nature (transient ischemic attack, stroke, etc..), coronary in nature (angina, myocardial infarction, etc..) or otherwise (claudication mesenteric, etc.), and objectively diagnosed.
- Systemic inflammatory disease: any history of systemic disease, lupus erythematosus or other connective, rheumatoid arthritis
- Any history of neoplastic disease
- Chronic antithrombotic treatment taken before the occurrence of obstetrical complications
- Any chronic immunosuppressive therapy or immunomodulatory therapy (eg corticosteroids, hydroxochloroquine or intravenous immunoglobulins)
- Fetal loss can be explained by infectious, metabolic (including rates of fasting blood glucose> 7 mmol / L), anatomical or hormonal factors
- History of infection with hepatitis B, hepatitis C or HIV
- Taking antipsychotic treatment potentially implicated in biological autoimmune abnormalities
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Suspected Obstetrical APS; confirmed APS Thrombophilia bloodwork The patients included in this study are women actively addressed to the participating departments because of clinical symptoms corresponding to suspected obstetrical anti-phospholipid syndrome. Bloodwork later confirms that these patients have APS. All patients included in this study will have the following interventions: * antiphospholipid antibody tests * thrombophilia bloodwork * psychiatric evaluation Sus. Obst. APS, confirmed thrombophilia Thrombophilia bloodwork The patients included in this study are women actively addressed to the participating departments because of clinical symptoms corresponding to suspected obstetrical anti-phospholipid syndrome. Bloodwork later confirms that these patients are thrombophilic. All patients included in this study will have the following interventions: * antiphospholipid antibody tests * thrombophilia bloodwork * psychiatric evaluation Suspected Obstectrical APS; unconfirmed Psychiatric evaluation The patients included in this study are women actively addressed to the participating departments because of clinical symptoms corresponding to suspected obstetrical anti-phospholipid syndrome. Bloodwork cannot confirm APS, nor thrombophilia. All patients included in this study will have the following interventions: * antiphospholipid antibody tests * thrombophilia bloodwork * psychiatric evaluation Sus. Obst. APS, confirmed thrombophilia Psychiatric evaluation The patients included in this study are women actively addressed to the participating departments because of clinical symptoms corresponding to suspected obstetrical anti-phospholipid syndrome. Bloodwork later confirms that these patients are thrombophilic. All patients included in this study will have the following interventions: * antiphospholipid antibody tests * thrombophilia bloodwork * psychiatric evaluation Suspected Obstectrical APS; unconfirmed Thrombophilia bloodwork The patients included in this study are women actively addressed to the participating departments because of clinical symptoms corresponding to suspected obstetrical anti-phospholipid syndrome. Bloodwork cannot confirm APS, nor thrombophilia. All patients included in this study will have the following interventions: * antiphospholipid antibody tests * thrombophilia bloodwork * psychiatric evaluation Suspected Obstetrical APS; confirmed APS Antiphospholipid antibody tests The patients included in this study are women actively addressed to the participating departments because of clinical symptoms corresponding to suspected obstetrical anti-phospholipid syndrome. Bloodwork later confirms that these patients have APS. All patients included in this study will have the following interventions: * antiphospholipid antibody tests * thrombophilia bloodwork * psychiatric evaluation Sus. Obst. APS, confirmed thrombophilia Antiphospholipid antibody tests The patients included in this study are women actively addressed to the participating departments because of clinical symptoms corresponding to suspected obstetrical anti-phospholipid syndrome. Bloodwork later confirms that these patients are thrombophilic. All patients included in this study will have the following interventions: * antiphospholipid antibody tests * thrombophilia bloodwork * psychiatric evaluation Suspected Obstectrical APS; unconfirmed Antiphospholipid antibody tests The patients included in this study are women actively addressed to the participating departments because of clinical symptoms corresponding to suspected obstetrical anti-phospholipid syndrome. Bloodwork cannot confirm APS, nor thrombophilia. All patients included in this study will have the following interventions: * antiphospholipid antibody tests * thrombophilia bloodwork * psychiatric evaluation Suspected Obstetrical APS; confirmed APS Psychiatric evaluation The patients included in this study are women actively addressed to the participating departments because of clinical symptoms corresponding to suspected obstetrical anti-phospholipid syndrome. Bloodwork later confirms that these patients have APS. All patients included in this study will have the following interventions: * antiphospholipid antibody tests * thrombophilia bloodwork * psychiatric evaluation
- Primary Outcome Measures
Name Time Method presence/absence of (lifetime) psychiatric symptoms baseline (transversal); Day 0 The Mini International Neuropsychiatric Interview (MINI 6) will be used to determined the presence/absence of (lifetime) psychiatric symptoms.
- Secondary Outcome Measures
Name Time Method presence/absence of allele JAK2 617F baseline (transversal); Day 0 JAK2 617F: 617f mutation at the jak2 gene
Age at beginning of psychiatric symptoms baseline (transversal); Day 0 in years
presence/absence of (current) psychiatric symptoms baseline (transversal); Day 0 The Mini International Neuropsychiatric Interview (MINI 6) will be used to determined the presence/absence of (current) psychiatric symptoms.
SCID-1 score baseline (transversal); Day 0 or up to Day 15 Structured Clinical Interview for Disorders (SCID-1) score for patients with a positive MINI evaluation.
MDQ score baseline (transversal); Day 0 Mood Disorder Questionnaire score
BDI score baseline (transversal); Day 0 or up to Day 15 The Beck Depression Inventory (BDI) score for currently depressed patients only.
IDS-C score baseline (transversal); Day 0 or up Day 15 Inventory of Depressive Symptomatology (IDS-C) for currently depressed patients.
presence/absence of lupus anticoagulant baseline (transversal); Day 0 presence/absence of anticardiolipid antibodies baseline (transversal); Day 0 presence/absence of anti-beta2-glycoprotein 1 antibodies baseline (transversal); Day 0 deficit in antithrombin: yes/no baseline (transversal); Day 0 Deficit in protein C: yes/no baseline (transversal); Day 0 Deficit in protein S: yes/no baseline (transversal); Day 0 Excess of FVIII: yes/no baseline (transversal); Day 0 Excess of coagulation factor VIII?
Excess of homocystein? yes/no baseline (transversal); Day 0 presence/absence of allele F5 1691A baseline (transversal); Day 0 F5 1691A: allele 1691A for the factor V leiden gene
presence/absence of allele F2 20210A baseline (transversal); Day 0 F2 20210A: allele 20210A for the prothrombin gene
Age at beginning of APL or thrombophilia symptoms baseline (transversal); Day 0 in years
Trial Locations
- Locations (5)
CHU de Montpellier - Hôpital Saint-Eloi
🇫🇷Montpellier, France
APHM - Hôpital Nord
🇫🇷Marseille Cedex 20, France
APHM - Hôpital de la Conception
🇫🇷Marseille Cedex 5, France
CHU de Nîmes - Hôpital Universitaire Carémeau
🇫🇷Nîmes Cedex 09, France
APHM - Hôpital La Timone Adultes
🇫🇷Marseille cedex 5, France