Clinical Pharmacist-led Appropriate Acid Suppression Therapy Stewardship Program

Not Applicable

Completed

• Conditions: Geriatric
• Interventions: Other: Clinical Pharmacist-led Appropriate Acid Suppression Therapy Stewardship Program

• Registration Number: NCT05113667
• Lead Sponsor: Marmara University

Brief Summary

To evaluate the impact of clinical pharmacist-led appropriate acid suppression therapy stewardship program in hospitalized older patients.

Detailed Description

This prospective, nonrandomized controlled study was conducted in older patients who ordered proton pump inhibitor (PPI) at admission in an internal medicine service of tertiary training and research hospital. In the intervention group, clinical pharmacist-led services (including medication reconciliation and medication review) were conducted during hospitalization and at discharge by using the guidelines and potentially inappropriate medications (PIM) criteria \[American Geriatric Society-AGS Beers Criteria©, 2019\]. Medication Appropriateness Index (MAI), inappropriate PPI cost, and hospitalization for gastrointestinal bleeding within 1 year after discharge were calculated in both groups

Study Timeline

• Study Start: 2019-09-01
• Primary Completion: 2020-02-28
• Study Completion: 2021-08-31
• Study First Submitted: 2021-10-17
• Study First Submitted QC: 2021-10-28
• Study First Posted: 2021-11-09
• Status Verified: 2023-10
• Last Update Submitted: 2023-10-17
• Last Update Posted: 2023-10-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

• 65 years old or greater
• Admitted to the hospital with any reason
• Ordered at least one PPI dose within 48 hours of admission

Exclusion Criteria

• Transferred to another ward (including an intensive care unit)
• Having active gastrointestinal bleeding
• Having active malignity

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Clinical pharmacist-led services	Clinical Pharmacist-led Appropriate Acid Suppression Therapy Stewardship Program	Clinical Pharmacist-led Appropriate Acid Suppression Therapy Stewardship Program

Primary Outcome Measures

Name	Time	Method
Appropriateness of Proton Pump Inhibitors Usage	during hospital stay, an average of 14 days	The rate of appropriateness use of proton pump inhibitors based on the guidelines at hospital stay
Potentially Inappropriate Proton Pump Inhibitors Usage	at discharge, an average of 14 days after admission to hospital	The rate of potentially inappropriate use of proton pump inhibitors based on American Geriatric Society Beers Criteria© 2019

Secondary Outcome Measures

Name	Time	Method
Clinical outcome	1 year	The number of patients who hospitalized for bleeding within 1 year after discharge
Cost saving during hospital stay	during hospital stay, an average of 14 days	Medication cost for inappropriate PPI during hospital study
Medication Appropriateness Index for Proton Pump Inhibitors at hospital stay	during hospital stay, an average of 14 days	Medication Appropriateness Index (MAI); included 10 items. Each item was weighted from 1-3. The highest score per medication was 18.; Higher scores of this index represent more inappropriateness of each medication.
Cost saving after discharge	a month	Medication cost for potentially inappropriate PPI after discharge
Medication Appropriateness Index for Proton Pump Inhibitors at discharge	at discharge, an average of 14 days after admission to hospital	Medication Appropriateness Index (MAI); included 10 items. Each item was weighted from 1-3. The highest score per medication was 18.; Higher scores of this index represent more inappropriateness of each medication.

Trial Locations

Locations (1)

Marmara University; 🇹🇷 Istanbul, Turkey