Immunological effects of an acellular pertussis booster vaccination in children, young adults and elderly with different immunisation background.An international study in Finland, the Netherlands and the United Kingdom - Booster Against Pertussis (BERT) Study

CTRG, University of Oxford0 个研究点目标入组 366 人开始时间: 2018年6月8日最近更新: 2020年12月14日

研究概览

暂无简介。

•Normal general health
•Within the right age group for the cohort
•Received all regular vaccines for their age group according to the Dutch NIP, UK NIP or Finnish NIP
•Provision of written informed consent
•Willing to adhere to the protocol and be available during the study period
•Are the trial subjects under 18? yes
•Number of subjects for this age range: 216
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 100
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 50

•Present evidence of serious disease(s) within the last 3 months before inclusion requiring immunosuppressive or immune modulating medical treatment, such as systemic corticosteroids, that might interfere with the results of the study;
•Chronic infection
•Known or suspected immune deficiency;
•History of any neurologic disorder, including epilepsy;
•Previous administration of serum products (including immunoglobulins) within 6 months before vaccination and blood sampling;
•Known and/or suspected allergy to any of the vaccine components (by medical history);
•Occurrence of a serious adverse events (SAEs) after primary DTwP-IPV vaccination, DTaP-IPV vaccination or any other vaccination (by medical history);
•Vaccination with any other pertussis vaccine other than those described in the inclusion criteria (i.e. only according to NIP)
•Vaccination with any other DT-IPV vaccine in the last 5 years, a DT-IPV vaccination according to NIP in cohort B is not an exclusion criterion;
•Children between 8 and 10 years of age eligible for cohort A in the Netherlands who have already received the diphtheria and tetanus toxoid vaccine (DT)-IPV booster vaccination according to Dutch NIP around 9 years of age;
•Mixed wP and aP priming within a participant, cohort B;
•Pregnancy.

发起方

CTRG, University of Oxford