Investigation of Human Alpha-fetoprotein Genes

• Conditions: Elevated or Normal Alpha-fetoprotein Patients

• Registration Number: NCT01258894
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Studies revealed that patients with hereditary persistence of AFP also had persistent abnormal AFP. Therefore, this study will recruit the patients and their family with elevated AFP (\>20 ng/mL) and normal AFP patients being control groups. Then, their AFP genes extracted from the blood will be analyzed.

Detailed Description

Abnormal AFP elevation was usually noted in liver regeneration, HCC, nonseminomatous germ cell tumors or other malignant tumors. However, some studies revealed that patients with hereditary persistence of AFP also had persistent abnormal AFP. Therefore, we study will recruit the patients and their family with elevated AFP (\>20 ng/mL) and normal AFP patients being control groups. Then, their AFP genes extracted from the blood will be analyzed. The hypothesis of this study is that the mutation of AFP gene might be one of the causes of abnormal AFP.

Study Timeline

• Study First Submitted: 2010-11-30
• Status Verified: 2010-12
• Study Start: 2010-12
• Study First Submitted QC: 2010-12-10
• Study First Posted: 2010-12-13
• Last Update Submitted: 2010-12-21
• Last Update Posted: 2010-12-22
• Primary Completion: 2013-10
• Study Completion: 2013-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• The patients and their family with elevated AFP (>20 ng/mL) and normal AFP patients being control groups. More than 20 years old

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Exclusion Criteria

• Pregnancy

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan