ITMCTR2000003996招募中1 期
Evaluation of the clinical curative effect of Wenyang Lishui Therapy in the treatment of refractory liver cirrhosis ascites
Shuguang Hospital Affiliated to Shanghai University of traditional Chinese Medicine0 个研究点开始时间: 待定最近更新:
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional study
入排标准
- 年龄范围
- 18 至 80（—）
- 性别
- All
入选标准
- •1. Male or female aged 18-80 years;
- •2. The western medicine diagnosis is cirrhosis refractory ascites, and the traditional Chinese medicine diagnosis is distension, the syndrome type conforms to the spleen and kidney yang deficiency syndrome.
- •Diagnostic criteria of Western medicine:
- •1. Diagnostic criteria of decompensated cirrhosis
- •(1) B ultrasound diagnosis of liver cirrhosis
- •(2) Complications of portal hypertension and / or liver dysfunction: child Pugh B / C grade; ascites, esophageal variceal bleeding, sepsis, hepatic encephalopathy, hepatorenal syndrome
- •2. Diagnostic criteria of ascites in refractory cirrhosis
- •(1) There was no response in ascites (4-6 g / D) with large diuretics (160 mg / D in snail and 80 mg / D in furosemide) for at least 1 week or intermittent therapeutic ascites drainage (4000-5000ml / time) combined with albumin (20-40g / time) for 2 weeks. Ascites did not respond to treatment (i.e. body weight decreased by less than 0.8kg/d, urinary sodium excretion was less than 50meq / D) or the ascites that had been controlled recurred within 4 weeks At least Grade 1);
- •(2) There were complications or adverse reactions related to diuretics that were difficult to control.
- •Diagnostic criteria of traditional Chinese Medicine
- •According to the diagnostic criteria of traditional Chinese medicine bloating, the main manifestations are abdominal fullness, short urine, even big abdomen, pale skin and exposed veins. The syndrome type accords with the deficiency of spleen and kidney yang.
- •Main symptoms: abdominal distension and fullness, like frog abdomen; abdominal distension early light, dusk heavy; limb cold;
- •Secondary symptoms: white complexion, swelling of limbs, soreness and weakness of waist and knee, cold pain in abdomen.
- •Tongue vein: the tongue is light and fat, or has teeth marks, the moss is thin and white, and the pulse is deep and stringy.
- •Diagnosis: there are 2 main symptoms and 2 secondary symptoms, or 3 secondary symptoms in the first major symptom.
排除标准
- •1. Patients with serious heart, lung, kidney, nervous system, blood system, psychosis and tumor (liver tumor only exclude those complicated with bloody ascites);
- •2. Patients with diabetes whose blood sugar is difficult to control;
- •3. Patients with liver cirrhosis complicated with upper gastrointestinal bleeding, grade 2 or higher hepatic encephalopathy.
- •4. Pregnant and lactating women;
- •5. Patients allergic to Zhenwu decoction;
- •6. Patients who are participating in other clinical trials.
研究者
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