Transciptomic Modification Induced by miRNAs in Endometrial Fluid

Not Applicable

Completed

• Conditions: MicroRNA in Endometrial Fluid
• Interventions: Procedure: Endometrial fluid aspiration

• Registration Number: NCT02554539
• Lead Sponsor: Stanford University

Brief Summary

The purpose of this study is to understand the mechanism of communication between the uterine environment and the preimplantation human embryo. The investigators are interested in understanding how the in-utero environment during the window of implantation is different in normal weight and overweight/obese women and how this may impact the programming of the developing embryo.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-07-01
• Study First Submitted: 2015-08-27
• Study First Submitted QC: 2015-09-17
• Study First Posted: 2015-09-18
• Primary Completion: 2017-07-01
• Study Completion: 2017-07-01
• Status Verified: 2018-04
• Last Update Submitted: 2018-04-18
• Last Update Posted: 2018-04-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 10

Inclusion Criteria

• Meet the WHO criteria for normal weight (BMI < 25) and overweight/obese (BMI > 25)
• Age 21-45

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Exclusion Criteria

• Age < 21 or > 45
• Women with history of hysterectomy

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Obese	Endometrial fluid aspiration	Women, aged 21-45 with BMI \>30
Normal weight	Endometrial fluid aspiration	Women, aged 21-45 with BMI \< 25

Primary Outcome Measures

Name	Time	Method
Gene expression profile in human embryos	Samples will be collected within 1 month of enrollment	We will perform RNA sequencing on the human embryo to quantify which genes are up and down regulated in obese compared to normal weight controls.

Trial Locations

Locations (1)

Stanford University; 🇺🇸 Stanford, California, United States