Human Embryonic Transciptomic Modification Induced by miRNAs Secreted by Human Endometrium to Endometrial Fluid
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Gene expression profile in human embryos
研究概览
简要总结
The purpose of this study is to understand the mechanism of communication between the uterine environment and the preimplantation human embryo. The investigators are interested in understanding how the in-utero environment during the window of implantation is different in normal weight and overweight/obese women and how this may impact the programming of the developing embryo.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Meet the WHO criteria for normal weight (BMI < 25) and overweight/obese (BMI > 25)
- •Age 21-45
排除标准
- •Age < 21 or > 45
- •Women with history of hysterectomy
研究组 & 干预措施
Obese
Women, aged 21-45 with BMI >30
干预措施: Endometrial fluid aspiration (Procedure)
Normal weight
Women, aged 21-45 with BMI < 25
干预措施: Endometrial fluid aspiration (Procedure)
结局指标
主要结局
Gene expression profile in human embryos
时间窗: Samples will be collected within 1 month of enrollment
We will perform RNA sequencing on the human embryo to quantify which genes are up and down regulated in obese compared to normal weight controls.
次要结局
未报告次要终点
研究者
Meera Sridhar Shah
Clinical Fellow
Stanford University