Test-retest Reliability of Lung Diffusing Capacity for Nitric Oxide During Light and Moderate Intensity Cycling Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 17
- 试验地点
- 1
- 主要终点
- Diffusing capacity for nitric oxide (DLNO)
研究概览
简要总结
This study investigates the test-retest reliability of the lung diffusing capacity for nitric oxide in healthy individuals during exercise.
详细描述
The aim of this study of to evaluate the test-retest reliability of single-breath lung diffusing capacity measurements for nitric oxide (DLNO) in healthy individuals during light and moderate intensity cycling exercise. Healthy subjects will perform repeated single-breath DLNO measurements during light (i.e., at 50% of the first ventilatory threshold) and moderate intensity exercise (i.e., 80% of the first ventilatory threshold) on a stationary cycle ergometer.
研究设计
- 研究类型
- 观察性
- 观察模型
- 队列研究
- 时间视角
- 前瞻性
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- Healthy
- Age 18 yrs and older
- Ability to follow study procedures and instructions in German
排除标准
- Any known cardiopulmonary or metabolic diseases (e.g., heart disease, diabetes mellitus etc)
- Obesity (BMI > 30kg/m2)
- Smoking (ex-smoker allowed; if they stopped smoking at least one year before the examination)
- Mental impairment leading to inability to cooperate
- Respiratory infection in the last two weeks
- Forced expiratory volume in 1s/ forced vital capacity (FEV1/FVC ratio) FEV1/FVC ratio < lower limit of normal according to equations by Quanjer et al. Eur Respir J 2012.
结局指标
主要结局
Diffusing capacity for nitric oxide (DLNO)
时间窗: At third study visit, approximately 1-2 weeks after second study visit
DLNO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.
次要结局
- Alveolar volume (VA)(At third study visit, approximately 1-2 weeks after second study visit)
- Diffusing capacity for carbon monoxide (DLCO)(At third study visit, approximately 1-2 weeks after second study visit)
- Diffusing capacity for nitric oxide (DLNO)(At third study visit, approximately 1-2 weeks after second study visit)
- Breath hold time (BHT)(At third study visit, approximately 1-2 weeks after second study visit)
研究者
研究点 (1)
标识符
- NCT 编号
- NCT04618302
- 其他研究编号
- 2020-01756
日期
- 首次提交
- (5年前)
- 首次发布
- (5年前)
- 主要完成日期
- (5年前)
- 研究完成日期
- (5年前)
- 最近核实
- 最近更新
- (5年前)
监管与共享
- FDA 监管药物
- 否
- 是否有结果
- 否