NCT02112825已完成不适用
Exercise as an Adjunct Therapy to Reduce Blood Pressure in Chronic Kidney Disease
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- blood pressure
研究概览
简要总结
The general objective of the study is to investigate the effect of regular aerobic exercise on resting and 24-hr blood pressure levels in men and women with stage 3-4 kidney disease and hypertension.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •• Non-diabetic and >18 years of age
- •Diagnosed kidney disease with associated hypertension:
- •Non-nephrotic range proteinuria at diagnosis
- •No active glomerular disease or concomitant systemic inflammatory disease (e.g. lupus)
- •Systolic blood pressure >130 and/or diastolic blood pressure >80 mm Hg (on medication)
- •An estimated glomerular filtration rate of between 60 ml/min and 15 ml/min.
- •Individuals must be able to provide informed consent
- •Perform walking exercise training on a treadmill
- •Be able to participate in a 12-week supervised exercise program.
排除标准
- •Currently participating in a formal exercise program
- •Diabetes, active glomerular disease, or systemic inflammatory disease
- •Requiring dialysis
- •Have an Hematocrit <27%
- •Uncontrolled hypertension (>200/110mmHg)
- •Peripheral vascular disease.
- •An inability to understand English or give consent. Other exclusion criteria are: any contraindications to exercise testing or training as indicated by the American College of Sports Medicine guidelines such as: Unstable coronary heart disease and symptomatic heart failure, exercise capacity limited by health problems such as angina, severe arthritis, or extreme dyspnea on exertion, progressive neuromuscular disease, pulmonary disease, or having undergone a coronary revascularization within the past 6 months prior to enrollment.
研究组 & 干预措施
Exercise
Experimental
12 weeks of blended supervised-home based exercise 3-4 times per week for 30-45 minutes
干预措施: Exercise (Behavioral)
control
No Intervention
Control group asked to continue usual activities
结局指标
主要结局
blood pressure
时间窗: at week 0 and at week 12
resting and 24-hour ambulatory blood pressure
次要结局
- effective vascular compliance(at week 0 and at week 12)
- endothelial function(at week 0 and at week 12)
- biomarkers associated with blood pressure(at week 0 and at week 12)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
The Role of Exercise Training in the Treatment of Resistant HypertensionResistant HypertensionNCT03090529Aveiro University60
已完成
不适用
An Exercise Intervention for Prostate Cancer Patients Receiving Androgen Deprivation TherapySide-effectsPhysical ActivityProstate CancerNCT02248350Georgetown University19
已完成
不适用
Alzheimer's Prevention Through ExerciseAlzheimer's DiseaseNCT02000583University of Kansas Medical Center117
已完成
不适用
ACE Inhibitors Combined With Exercise for Seniors - Pilot StudyAgingHypertensionNCT01891513University of Florida104
已完成
不适用
Exercise Training in Patients With Mild COPDCOPDNCT02930421Pontificia Universidad Catolica de Chile30