Study to determine levels of Fibroblast Growth Factor 23 and other associated markers of bone turnover in men with various iron store states of iron overload, iron deficiency and normal iron stores.

Not Applicable

Recruiting

• Conditions: iron deficiency; iron overload; normal iron stores; bone metabolism; Metabolic and Endocrine - Other metabolic disorders; Diet and Nutrition - Other diet and nutrition disorders

• Registration Number: ACTRN12613000594729
• Lead Sponsor: Associate Professor Emily Hibbert

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-05-27
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: Male
• Target Recruitment: 140

Inclusion Criteria

The study population will comprise males of age 35 years or greater who meet one of the following criteria:
1.iron overload due to haemochromatosis with ferritin > 300microg/l, the upper limit of the reference range or
2.normal iron studies
3.iron deficiency with ferritin < 30 microg/l ie. below the lower limit of the reference range

Exclusion Criteria

1.Intercurrent proven evidence of cancer – as this will affect ferritin levels and interpretation and may alter FGF 23
2.Active infection- will affect ferritin levels and interpretation and may alter FGF 23
3.Chronic kidney disease with eGFR< 50 - as eGFR drops, FGF23 levels rise rapidly
4.Current glucocorticoid use,
5.Hypercalcaemia
6.Vitamin D deficiency with 25OH vitamin D level < 25 nmol/l

Study & Design

• Study Type: Observational
• Study Design: Not specified