NCT00021047已完成1 期
A Phase I/II Trial of Epirubicin, Carboplatin & Capecitabine in Adult Cancer Patients
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 试验地点
- 6
研究概览
简要总结
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase I/II trial to study the effectiveness of combining epirubicin, carboplatin, and capecitabine in treating patients who have unresectable locally advanced, metastatic, or recurrent solid tumor.
详细描述
OBJECTIVES:
- Determine the maximum tolerated dose and the recommended phase II dose of capecitabine administered with epirubicin and carboplatin in patients with unresectable locally advanced, metastatic, or recurrent solid tumors.
- Determine the toxic effects of this regimen in these patients.
- Determine the pharmacokinetics (PK) of capecitabine and correlate these PK parameters with clinical toxicity of this regimen in these patients.
- Correlate end-of-infusion levels of epirubicin and its metabolites with epirubicin dose and clinical toxicity of this regimen in these patients.
- Determine the possible correlation between polymorphisms in the promoter region of the thymidylate synthase gene with clinical toxicity of this regimen in these patients.
- Determine the antitumor activity of this regimen in these patients.
OUTLINE: This is a dose-escalation study of capecitabine.
Patients receive epirubicin IV over 2 hours and carboplatin IV over 30 minutes on day 1 and oral capecitabine twice daily on days 2-5, 8-12, and 15-19. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.
Cohorts of 3-6 patients receive escalating doses of capecitabine until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. Once the MTD is determined, 24 additional patients are treated at the recommended phase II dose.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •DISEASE CHARACTERISTICS:
- •Histologically confirmed solid tumor
- •Progressive disease on standard therapy, including:
- •Locally advanced, unresectable primary or recurrent tumor OR
- •Metastatic disease
- •Previously untreated metastatic cancer for which study regimen represents reasonable initial chemotherapy with palliative intent (e.g., metastatic gastric cancer, hepatobiliary cancer, or cancers for which no effective standard therapy exists) allowed
- •Phase II portion:
- •Diagnosis of cancer of the upper aerodigestive tract (head and neck, esophagus, stomach, or hepatobiliary)
- •No potential curative treatment options including surgery, radiotherapy, chemoradiotherapy, or combination chemotherapy
- •No leukemia or lymphoma
- •No primary CNS malignancies or CNS metastases
- •PATIENT CHARACTERISTICS:
- •18 and over
- •Performance status:
- •Life expectancy:
- •Not specified
- •Hematopoietic:
- •Absolute granulocyte count at least 2,000/mm^3
- •Platelet count at least 100,000/mm^3
- •Bilirubin no greater than 1.5 mg/dL
- •AST and ALT no greater than 2.5 times upper limit of normal
- •Creatinine no greater than 1.6 mg/dL
- •Cardiovascular:
- •LVEF at least 50%
- •No symptomatic congestive heart failure
- •No unstable angina
- •No cardiac arrhythmia
- •No serious concurrent medical illness that would preclude study participation
- •No active infections requiring IV antibiotic therapy
- •No history of allergy to platinum compounds, mannitol, or antiemetics used with study drugs
- •No history of severe intolerance to fluorouracil
- •Not pregnant or nursing
- •Negative pregnancy test
- •Fertile patients must use effective contraception
- •PRIOR CONCURRENT THERAPY:
- •Biologic therapy:
- •More than 4 weeks since prior immunotherapy and recovered
- •Chemotherapy:
- •See Disease Characteristics
- •More than 4 weeks since prior chemotherapy (at least 6 weeks for nitrosoureas or mitomycin) and recovered
- •No prior cumulative doxorubicin dose of more than 300 mg/m2
- •Endocrine therapy:
- •Not specified
- •Radiotherapy:
- •See Disease Characteristics
- •At least 2 weeks since prior radiotherapy and recovered
- •At least 8 weeks since prior strontium chloride Sr 89
- •See Disease Characteristics
- •Recovered from prior surgery
- •At least 4 weeks since prior sorivudine or brivudine
- 另有 3 项未显示
排除标准
- 未提供
研究者
研究点 (6)
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