Phase II Study of Campath-1H (NSC #950010) and Peripheral Blood Stem Cell Transplant for Patients With Chronic Lymphocytic Leukemia
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 试验地点
- 14
研究概览
简要总结
RATIONALE: Monoclonal antibodies such as alemtuzumab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy. Combining monoclonal antibody therapy, chemotherapy, radiation therapy, and peripheral stem cell transplantation may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of alemtuzumab plus peripheral stem cell transplantation in treating patients who have chronic lymphocytic leukemia.
详细描述
OBJECTIVES:
- Determine the ability of in vivo purging with alemtuzumab (monoclonal antibody CD52; Campath-1H) to produce a stem cell graft without detectable leukemia cells in patients with chronic lymphocytic leukemia.
- Determine the ability to successfully mobilize stem cells after in vivo purging with monoclonal antibody CD52 in these patients.
- Determine the toxicity of this treatment regimen in these patients.
- Determine the response to this treatment regimen in these patients at 6 months after peripheral blood stem cell transplantation.
OUTLINE: This is a multicenter study.
Patients receive induction therapy comprising alemtuzumab (monoclonal antibody CD52; Campath-1H) IV over 2 hours three times a week for 4 weeks.
Beginning no more than 2 weeks after induction therapy, patients receive mobilization chemotherapy comprising cyclophosphamide IV over 1-2 hours on day 1 and filgrastim (G-CSF) subcutaneously (SC) starting on day 2 and continuing until the last day of apheresis. Patients undergo peripheral blood stem cell apheresis on days 10-14.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •DISEASE CHARACTERISTICS:
- •Diagnosis of chronic lymphocytic leukemia (CLL) that meets the following criteria at any point prior to study entry:
- •Peripheral blood absolute blood count greater than 5,000/mm^3
- •Lymphocytosis must comprise small to moderate size lymphocytes with no more than 55% prolymphocytes, atypical lymphocytes, or lymphoblasts morphologically
- •Phenotypically characterized B-cell CLL
- •Splenomegaly, hepatomegaly, or lymphadenopathy not required for CLL diagnosis
- •Must have bone marrow biopsy within 4 weeks of study entry showing cellularity of at least 25% of intratrabecular space and lymphocytes accounting for no more than 30% of nucleated cells
- •PATIENT CHARACTERISTICS:
- •Performance status:
- •Life expectancy:
- •Not specified
- •Hematopoietic:
- •See Disease Characteristics
- •Absolute neutrophil count at least 1,000/mm^3
- •Hemoglobin at least 11 g/dL
- •Platelet count at least 100,000/mm^3
- •Bilirubin no greater than 2 mg/dL (unless secondary to tumor)
- •AST or ALT less than 3 times upper limit of normal
- •Hepatitis B surface antigen negative
- •Hepatitis C RNA negative
- •Creatinine no greater than 2.0 mg/dL
- •Cardiovascular:
- •Left ventricular ejection fraction at least 45% by echocardiogram or MUGA
- •DLCO, FEV_1, and FVC greater than 50% of predicted
- •No active infection requiring oral or IV antibiotics
- •No other prior malignancy within the past two years except basal cell skin cancer or carcinoma in situ of the cervix
- •HIV negative
- •Not pregnant or nursing
- •Negative pregnancy test
- •Fertile patients must use effective contraception
- •PRIOR CONCURRENT THERAPY:
- •Biologic therapy:
- •Prior monoclonal antibody CD52 allowed if at least partial remission was achieved with last treatment
- •Chemotherapy:
- •No more than 2 prior chemotherapy regimens
- •At least 3 weeks since prior chemotherapy
- •No more than 8 courses of prior fludarabine therapy
- •Endocrine therapy:
- •Not specified
- •Radiotherapy:
- •Not specified
- •Not specified
排除标准
- 未提供