Comparison of the Effect of Injectable Platelet-rich Fibrin and Advanced Platelet-rich Fibrin With Xenograft on the Socket Preservation of Mandibular Extracted Molars ( a Randomised Controlled Clinical Trial) Comparison of the Effect of Injectable Platelet-rich Fibrin and Advanced Platelet-rich Fibrin With Xenograft on the Socket Preservation of Mandibular Extracted Molars ( a Randomised Controlled Clinical Trial)
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 16
- Locations
- 1
- Primary Endpoint
- Change in healing
Study Overview
Brief Summary
Different materials and techniques are employed for socket preservation to reduce the alveolar bone resorption in both the horizontal and vertical dimensions as well as the soft tissue collapse after tooth extraction. Because of the repair abilities of the growth factors and proteins released by platelets, the development and application of platelet-enriched preparations have revolutionised the area of regenerative medicine.The present study will be designed to study the difference between A-PRF and IPRF with the addition of Xenograft in the preservation of bone in mandibular molars.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients who need extraction of hopeless mandibular molars
- •Teeth with advanced caries not amenable for conservative treatment
- •Patients who are willing and fully capable of complying with the study protocol.
Exclusion Criteria
- •Systemic diseases that prevent surgery
- •Acute or chronic oral infections
- •Periodontal diseases
- •Heavy smokers or alcoholics
- •On anticoagulant drugs.
- •Pregnancy
- •History of radiotherapy or chemotherapy of the head and neck region
Arms & Interventions
Control
Intervention: Control (Other)
A-PRF
Intervention: A-PRF (Other)
I-PRF
Intervention: I-PRF (Other)
Outcomes
Primary Outcomes
Change in healing
Time Frame: Baseline and 12 weeks
A modified Landry, Turnbull, and Howley healing index will be used to assess wound healing (HI). This entails evaluating the following parameters in a comparative manner using a dichotomic score (1/0). Tissue colour or the presence or absence of redness to indicate inflammatory processes; granulation tissue; suppuration; swelling; degree of tissue epithelialisation (partial or complete); and the presence or absence of bleeding and tenderness on palpation
change in bone density
Time Frame: Baseline and 12 weeks
Bone density will be measured using CBCT examinations
Secondary Outcomes
No secondary outcomes reported
Investigators
Hams Hamed Abdelrahman
Lecturer of Dental Public Health and biostatistical consultanat
Alexandria University