Low Tube Voltage Computed Tomographic (CT) Urography Using Low Concentration Iodine Contrast Agent

Not Applicable

• Conditions: Exposure to Medical Diagnostic Radiation
• Interventions: Radiation: Computed tomographic urography

• Registration Number: NCT01855204
• Lead Sponsor: Seoul National University Hospital

Brief Summary

Computed Tomographic (CT) urography is the best imaging modality to evaluate obstructing lesions of urinary tract such as urinary stone, tumor and inflammatory lesion. The purpose of our study is to compare images of CT urography performed by low voltage and low concentrated iodine CT contrast with them of conventional CT urography.

Detailed Description

Computed Tomographic (CT) urography is the best imaging modality to evaluate obstructing lesions of urinary tract such as urinary stone, tumor and inflammatory lesion. It is needed that CT urography should have the high contrast between target lesion described as filling defect and adjacent contrast filled urinary tract. For the implementation of high contras, conventional CT urography has been performed with higher voltage and higher concentrated CT contrast than another CT protocols. The higher voltage results in the more radiation exposure. And the intravenous injection of higher concentrated CT contrast results in the increase of the prevalence of contrast induced nephrotoxicity.

The purpose of our study is to compare images of CT urography performed by low voltage and low concentrated iodine CT contrast with them of conventional CT urography.

Study Timeline

• Study Start: 2013-04
• Study First Submitted: 2013-04-27
• Study First Submitted QC: 2013-05-13
• Study First Posted: 2013-05-16
• Status Verified: 2013-12
• Last Update Submitted: 2013-12-03
• Last Update Posted: 2013-12-04
• Primary Completion: 2014-02
• Study Completion: 2014-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

• Patients to perform Computed Tomographic (CT) urography
• Patients without diminish of renal function (serum creatinine: more than 1.4 mg/dl & glomerular filtration rate: more than 34 mL/min/1.73 m2)

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Exclusion Criteria

• patients to have operations and/or injuries of urinary system
• patients to have the histories of anaphylaxis or allergic reaction about intravenous iodine contrast material

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Conventional	Computed tomographic urography	Computed tomographic urography was done with conventional protocols.
Reduced	Computed tomographic urography	Computed tomographic urography was done with the protocols of low voltage and low iodine concentration.

Primary Outcome Measures

Name	Time	Method
Measurement of Radiation Dose	The day of admission (within 24hours)

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of