Cold Water Immersion Modulates Reinforcing Effects of Nitrous Oxide
Overview
- Phase
- Phase 2
- Status
- Completed
- Sponsor
- University of Chicago
- Enrollment
- 12
- Locations
- 1
- Primary Endpoint
- Subject's choice of intervention
Overview
Brief Summary
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To evaluate: cold water immersion modulates the reinforcing effects of nitrous oxide in healthy volunteers.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 21 Years to 32 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
Lukewarm water
Subjects will immerse forearm in lukewarm water while inhaling 0% and 40% N2O in 2 sampling trials, then choose between intervntions for one choice trial
Intervention: 0% N2O (Drug)
Lukewarm water
Subjects will immerse forearm in lukewarm water while inhaling 0% and 40% N2O in 2 sampling trials, then choose between intervntions for one choice trial
Intervention: 40% N2O (Drug)
Ice cold water
Subjects will immerse forearm in ice cold water while inhaling 0% and 40% N2O in 2 sampling trials, then choose between intervntions for one choice trial
Intervention: 0% N2O (Drug)
Ice cold water
Subjects will immerse forearm in ice cold water while inhaling 0% and 40% N2O in 2 sampling trials, then choose between intervntions for one choice trial
Intervention: 40% N2O (Drug)
Outcomes
Primary Outcomes
Subject's choice of intervention
Time Frame: After sampling trials
Secondary Outcomes
No secondary outcomes reported