A study for all children and adolescents with a low grade glioma.

Completed

Conditions: low grade glioma, laaggradig glioom

Registration Number: NL-OMON20306

Lead Sponsor: International: SIOPDe voorzitter van de Trial Management Committee:Dr. Astrid K. GnekowI. Klinik fuer Kinder und Jugendliche, Klinikum AugsburgStenglinstrasse.4D-86156 Augsburg, GermanyNational: Dutch Childhood Oncology Group (DCOG)

Brief Summary: /A

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 100

Inclusion Criteria

1. Age: Children and adolescents up to age 16 years;

2. Histology: Glioma of low grade malignancy ( ICD O-Codes: 9421/1, 9384/1, 9413/0, 9412/1, 9505/1, 9424/3, 9450/3, 9382/3, 9400/3, 9420/3, 9410/3, 9411/3);

Exclusion Criteria

1. Primary tumor localization: Diffuse intrinsic tumors of the pons, even if histologically an Astrocytoma II° is diagnosed. Exception: pontine glioma II° in NF I patients may be entered into the study;

2. Special diagnosis: Patients presenting with rare intracranial neoplasms of low grade malignancy, but non-glial origin. Their data may be registered however, to learn about those therapeutic interventions which may prove useful to these patients and to develop separate strategies in the future. Choroid plexus papilloma should be entered on the SIOP-CPT-study;

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Progression Free Survival.

Secondary Outcome Measures

Name	Time	Method
1. Overall survival;<br /><br>2. Assessment of integral dose to tumor and normal tissue and evaluation on the impact on long – term toxicity;<br /><br>3. Assessment of tumor response to radiotherapy by imaging and clinical investigations;<br /><br>4. Assessment of progression-free and overall survival, acute and long-term toxicity of crnio-spinal irradiation in metastatic disease.