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临床试验/NCT06347913
NCT06347913尚未招募不适用

Umblical Artery Systolic \Diastolic Ratio and Amniotic Fluid Index in Prediction of Fetal

Sohag University1 个研究点 分布在 1 个国家目标入组 213 人开始时间: 2024年4月最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
213
试验地点
1
主要终点
Umbilical Artery Systolic/Diastolic Ratio

研究概览

简要总结

Antepartum fetal surveillance is the cornerstone of management in pregnancy. [1] It is done primarily to reduce the incidence of adverse fetal outcomes. It minimizes morbidity by optimizing the timing of delivery. Fetus at risk of chronic hypoxia is identified and unnecessary interventions are avoided. However, fetal surveillance acts as a diagnostic modality to detect the influence of maternal, placental, and fetal factors on the fetus. The timely detection of morbid changes in the fetal status followed by adequate interventions to avoid death or disability is one of the most important objectives of prenatal care. [2] Tests now commonly done for antepartum fetal surveillance are nonstress test (NST), amniotic fluid index (AFI), biophysical profile, Doppler study of umbilical artery (UA), and middle cerebral artery (MCA).[3 6] However, AFI and UA Doppler velocimetry both form an essential part of the antenatal surveillance in the assessment of fetal well being. UA Doppler is a powerful tool that allows the obstetrician to follow a sequence of fetal hemodynamic events that happen in response to placental insufficiency. [7] However, several studies have reported higher sensitivities and specificities for UA Doppler ratio for prediction of fetal prognosis. [3 6] Amniotic fluid is the product of complex and dynamic fetal and placental physiologic processes. Disruption of the fine balance may result in overproduction or underproduction of fluid. Liquor adequacy often reflects the fetal status. Oligohydramnios is associated with increased perinatal loss. Furthermore, other studies indicate that UA velocimetry is a predictor of adverse outcomes in pregnancies complicated by oligohydramnios. [8,9] Thus, arterial Doppler velocimetry measurement may be useful in predicting adverse pregnancy outcomes adjunct to other antenatal surveillance tests, especially the AFI. Therefore, the present study will be done to evaluate the comparative assessment of UA ratio and AFI in predicting adverse perinatal outcomes.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 40 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • * Age of mother 18-40 years
  • Term pregnancy (37w6d -40w)
  • Singleton pregnancy

排除标准

  • *Multiple pregnancy
  • Preterm pregnancy before 37w
  • Preeclampsia
  • Congenital anomalies of fetus

结局指标

主要结局

Umbilical Artery Systolic/Diastolic Ratio

时间窗: 6 months

Umblical Artery Systolic/Diastolic Ratio

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Sabrin Alnokrashy Mohamed

resident at obstetric and gynacology department at sohag university hospial

Sohag University

研究点 (1)

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