The Effects of Exogenous Ketones on Exercise Performance in Young Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Respiratory Exchange Ratio (RER) during cycling exercise
研究概览
简要总结
The ketone body beta-hydroxybutyrate is produced during prolonged fasting or exercise and can be used as an alternative fuel source. Exogenous beta-hydroxybutyrate, in the form of a ketone salt, is proposed to have ergogenic potential for high-intensity exercise performance but this has not been adequately studied. The purpose of this study is to determine whether supplementing with an acute dose of ketone salts can alter fuel use during exercise and improve exercise performance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Males aged 18-40
- •Ability to understand and communicate in English to answer questionnaires and interact with the research assistant
- •Physically active (defined by engaging in moderate-to-vigorous exercise at least 3 times per week, determined via validated questionnaire)
排除标准
- •Diagnosed with diabetes or any other medical conditions that could affect metabolism.
- •Diagnosed with heart disease or taking anti-hypertensive medications.
- •Competitive endurance athlete (self-identified as engaged in specific endurance training in triathlon, cycling, or distance running and competing in races or competition)
- •Recent (last 3 months) or current consumption of a low-carbohydrate ketogenic diet
- •Current consumption of ketone supplements
- •Any other contraindication to vigorous exercise (identified via physical activity readiness questionnaire [PAR-Q])
研究组 & 干预措施
Ketone Salts
Acute dose of beta-hydroxybutyrate potassium/sodium salt (0.2g beta-hydroxybutyrate/kg, 0.01g Potassium/kg, 0.01g Sodium/kg with 1 g Steviol Glycoside and 30 ml of lemon juice per dose)
干预措施: Ketone Salt (Dietary Supplement)
Placebo
Acute dose of taste-matched placebo (0.01g Potassium/kg, 0.01g Sodium/kg with 1 g Steviol Glycoside and 30 ml of lemon juice per dose)
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
Respiratory Exchange Ratio (RER) during cycling exercise
时间窗: 0-18 minutes
The RER during 18 minutes of steady-state exercise
次要结局
- 10 km Cycling Time Trial Performance(Following 18 minutes of steady-state exercise)
研究者
Jonathan Little
Assistant Professor
University of British Columbia