Pulsed Intravenous Methylprednisolone for Ocular Pemphigoid- A Pilot Study - IVMP for ocular pemphigoid

Moorfields Eye Hospital NHS Foundation Trust0 个研究点目标入组 20 人开始时间: 2005年8月23日最近更新: 2019年11月25日

适应症

试验速览

暂无简介。

•1. Patients with clinical features consistent with ocular MMP i.e. progressive conjunctival cicatrisation and inflammation, with or without a positive result on direct immunofluorescence microscopy of a conjunctival, mucosal or skin biopsy showing linear basement membrane deposition of IgG, IgA, or C3, and/or a positive result on testing for anti-basement membrane zone antibodies.
•2. All patients with bilateral or unilateral ‘severe’ (grade 4) ocular inflammation
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•1. other causes of progressive conjunctival scarring (drug-induced pemphigoid with negative direct immunofluorescence biopsy, atopic keratoconjunctivitis, Sjogren’s syndrome, Stevens Johnson syndrome, chemical injury)
•2. active secondary malignancy
•3. HIV infection
•4. pregnancy or breastfeeding.

发起方