Study to compare the difference between the outcomes of liver transplant between usage of synthetic graft(PTFE) vs native tissue graft(portal vein)
Not Applicable
- Conditions
- Health Condition 1: null- DECOMPENSATED CHRONIC LIVER DISEASE PATIENTS REQUIRING LIVER TRANSPLANTATIO
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
ADULT to ADULT LIVE DONOR LIVER TRANSPLANT PATIENTS with Decompensated Liver Disease (Acute/Subacute/Chronic)
Live Donor suitable for Right lobe donation with
1. Functional Liver Reserve > 30%
2. Adequate Segment 4 drainage to the Left Hepatic Vein
3. Steatosis < 20% assesses by Plain CT
Exclusion Criteria
PORTAL VEIN THROMBOSIS IN THE RECIPIENT
HEPATOCELLULAR CARCINOMA IN THE RECIPIENT
ABO Incompatible Transplants
DONOR - TYPE II or TYPE III Portal vein anatomy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method GRAFT PATENCY RATE assessed by DUPLEX ULTRASONOGRAM and confirmed with cross sectional imaging either CT or MRI in the event of thrombosis detected by DuplexTimepoint: First two weeks (daily doppler in the first week and alternate day doppler in the second week) <br/ ><br>at weekly intervals till 90 days
- Secondary Outcome Measures
Name Time Method GRAFT FUNCTION : <br/ ><br>EARLY ALLOGRAFT DYSFUNCTION <br/ ><br>PRIMARY NON FUNCTION <br/ ><br>SMALL FOR SIZE DYSFUNCTION <br/ ><br>Timepoint: First two weeks;ICU Stay <br/ ><br>Hospital Stay <br/ ><br>90 Day mortality <br/ ><br> <br/ ><br>Between patent vs thrombosed group <br/ ><br>Sepsis specific mortality <br/ ><br>90 day mortalityTimepoint: 90 days <br/ ><br>;MORBIDITY : <br/ ><br>Complications : <br/ ><br>Infections (intra-abdominal and blood borne) <br/ ><br>Vascular : <br/ ><br>Hepatic Artery thrombosis <br/ ><br>Portal vein thrombosis <br/ ><br>Biliary : <br/ ><br>Bile leak <br/ ><br>Immunological : <br/ ><br>Acute cellular rejection <br/ ><br>Interventions : <br/ ><br>Reexploration <br/ ><br>Percutaneous drainage of collectionTimepoint: First 2 weeks