Evaluating Myocardial Ischemia and Sympathetic Innervation in Patients with Chronic Kidney Disease before and during Renal Replacement Therapy using 99mTc-tetrofosmin and 123I-MIBG imaging

Completed

• Conditions: chronic kidney disease; dialysis; 10007521; 10038430

• Registration Number: NL-OMON37178
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 65

Inclusion Criteria

end-stage chronic kidney disease (stage 5)

Exclusion Criteria

Patients with acute or previous myocardial infarction within 6 months prior to inclusion, angina pectoris within 6 months prior to inclusion, known coronary artery disease within 6 months prior to inclusion, or recent acute cardiac decompensation, as defined by sudden accumulation of pulmonary congestion or peripheral oedema, pregnancy, M. Parkinson, diabetes mellitus, Diffuse Lewy Body disease. Use of tricyclic antidepressant agents (interferes with 123I- MIBG uptake). Participation to a previous protocol involving radioactivity in the past year.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Cardiac ischemia and cardial neuropathy in patients with CKD (pre-dialysis) and<br /><br>3 months after starting HD.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-</p><br>