Physical activity and body composition in patients with Ankylosing Spondylitis

Completed

• Conditions: Ankylosing Spondylitis; 10023213

• Registration Number: NL-OMON30954
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Patients, between the age of 18 and 65, diagnosed with Ankylosing Spondylitis (AS) according to the New York Criteria for AS, with a BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) >4, eligible for anti-TNF therapy according to the national guidelines.
Healthy controls: same gender, age within 5 years (and between 18 and 65) and family member of the respective patient.

Exclusion Criteria

Patients with other conditions known to affect energy metabolism (energy intake and/or expenditure) such as chronic inflammatory disorders (inflammatory bowel disease, COPD, rheumatoid arthritis,..), malignancies, AIDS, dieting will be excluded.
Controls will be excluded when any disorder known to affect energy metabolism is present (Ankylosing Spondylitis or any disorder listed above).
Subjects that meet any of the exclusion criteria for MRI (electronic implants, pacemakers, metal fragments in the eyes, skin or body) will be excluded.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>muscle mass (body compostition), physical activity, physical fitness, markers<br /><br>of inflammation and muscle metabolism</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>questionnaire assessed quality of life, disease activity, fatigue</p><br>