Ultrasound-guided Adductor Canal Block for Total Knee Replacement: a Randomized, Double-blind Placebo Controlled Trial.
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Opioid Consumption (mg morEq)
研究概览
简要总结
Total knee arthroplasty is associated with intense early postoperative pain. Fast track recovery programs including early therapy protocols and early hospital discharge are being implemented at various hospitals. The postoperative analgesic pain regimen should enhance functional recovery in addition to providing efficient analgesia with minimal side effects. Adductor canal blockade is commonly used to provide postoperative analgesia for total knee arthroplasty (TKA) surgery. The investigators hypothesize that an ultrasound guided adductor canal block will lower narcotic consumption and improved overall satisfaction compared to ultrasound guided sham block with normal saline (placebo) for patients undergoing minimally invasive TKA surgery.
详细描述
The investigators hypothesize that an ultrasound guided adductor canal block will lower narcotic consumption and improved overall satisfaction compared to ultrasound guided sham block with normal saline (placebo) for patients undergoing minimally invasive TKA surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Participants 40 to 75 years old who are presenting for minimally invasive total knee arthroplasty under spinal anesthesia
排除标准
- •Patient refusal
- •American Society of Anesthesiologists physical status classification of 4 or higher
- •Pre-existing neuropathy in the femoral or sciatic distribution
- •Coagulopathy
- •Infection at the site
- •Chronic opioid use (greater than 3 months)
- •Pregnancy
- •Medical conditions limiting physical therapy participation
- •Any other contra-indication to regional anesthesia
研究组 & 干预措施
Active Group
Ultrasound-guided adductor canal blockade with 10 ml of 0.25% bupivacaine
干预措施: Bupivacaine (Drug)
Control Group
Ultrasound-guided sham block with 10 ml of preservative free normal saline
干预措施: Preservative free normal saline (Drug)
结局指标
主要结局
Opioid Consumption (mg morEq)
时间窗: 36 hours
Opioid consumption (morphine equivalents)
次要结局
- Length of Hospitalization(0 to 192 hours)
- Visual Analog Scale Pain Score(Pain burden at 36hr)
研究者
Antoun Nader
Professor of Anesthesiology
Northwestern University