Effect of an Enhanced Recovery After Surgery Program on Outcomes After Pancreatoduodenectomy

Recruiting

• Conditions: Pancreatectomy; Enhanced Recovery After Surgery; Pancreatic Cancer Resectable

• Registration Number: NCT06935448
• Lead Sponsor: University of Thessaly

Brief Summary

This study assesses whether patients with pancreatic cancer who undergo surgery experience improved outcomes following the implementation of a multidisciplinary care pathway, specifically an enhanced recovery after surgery (ERAS) program.

This pathway includes various interventions in the preoperative, intraoperative, and postoperative care of these patients, all aimed at enhancing their health status and postoperative results.

Detailed Description

This prospective observational study is conducted by the same surgical team at two high-volume pancreatic cancer referral centers in Greece.

Patients undergoing elective pancreatic surgery are prospectively enrolled and managed according to a standardized ERAS protocol (ERAS group).

A control group, which received standard perioperative care before the implementation of ERAS, was retrospectively selected and matched based on demographic and clinical parameters.

The primary study endpoint is the length of hospital stay (LOS), while secondary endpoints include 30-day mortality and morbidity.

Study Timeline

• Study Start: 2019-07-01
• Status Verified: 2025-04
• Study First Submitted: 2025-04-08
• Study First Submitted QC: 2025-04-16
• Last Update Submitted: 2025-04-16
• Study First Posted: 2025-04-20
• Last Update Posted: 2025-04-20
• Primary Completion: 2025-04-30
• Study Completion: 2025-05-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 170

Inclusion Criteria

• adult patients
• diagnosis of pancreatic cancer
• elective open pancreatic surgery

Exclusion Criteria

• age <18 years
• emergency pancreatic surgery
• other surgical procedures
• missing data
• lost to follow-up

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
impact on length of stay	within 30 days of surgery	total number of days spent in the hospital including any readmission

Secondary Outcome Measures

Name	Time	Method
impact on overall morbidity	within 30 days from surgery	number of any perioperative adverse events

Trial Locations

Locations (1)

University of Thessaly; 🇬🇷 Larissa, Greece