NCT01419509已完成不适用
DNA Methylation-based Assays for Detecting Disease Spread in Rhabdomyosarcoma
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 170
- 主要终点
- Panel of hypermethylation assays for minimal disseminated RMS
研究概览
简要总结
RATIONALE: DNA analysis of tumor, blood, and bone marrow may help doctors predict if the disease has been disseminated.
PURPOSE: This research trial studies DNA tests in detecting disseminated disease in tumor, blood, and bone marrow samples from patients with rhabdomyosarcoma.
详细描述
OBJECTIVES:
- To establish a panel of hypermethylation assays for minimal disseminated disease analysis in rhabdomyosarcoma (RMS).
- To apply the hypermethylation assays to a series of bone marrow specimens from RMS patients.
OUTLINE: Archived tumor, bone marrow, and peripheral blood samples are analyzed for DNA hypermethylation by PCR-based assays and microarray assays. Results are then compared with each patient's clinical and pathological characteristics, and outcomes. Patterns of locus hypermethylation in tumor and paired bone marrow samples are also compared.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Panel of hypermethylation assays for minimal disseminated RMS
Detection of RMS cells in bone marrow
次要结局
未报告次要终点
研究者
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