An open randomised comparison of Gatifloxacin versus Cefixime for the treatment of uncomplicated enteric fever
Completed
- Conditions
- Enteric feverInfections and Infestations
- Registration Number
- ISRCTN75784880
- Lead Sponsor
- niversity of Oxford (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 169
Inclusion Criteria
1. The treating physician believes the diagnosis to be enteric fever
2. More than or equal to three days history of fever, headache and oral temperature more than or equal to 37.8 °C
Exclusion Criteria
1. Complicated typhoid (jaundice, shock, peritonism, gastrointestinal bleeding, myocarditis, encephalopathy)
2. Pregnancy
3. Lactation
4. Allergy to study drug
5. Quinolone, fluoroquinolone, macrolide or 3rd generation cephalosporin treatment within previous week
6. Unable to take oral medication
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Time to fever clearance
- Secondary Outcome Measures
Name Time Method 1. Development of complications<br>2. Blood culture sterilisation<br>3. Eradication of stool carriage<br>4. Need for retreatment<br>5. Development of enteric fever in household contacts<br>6. Treatment failure