Integrated Pulmonary Index as a Predictor of Respiratory Compromise in Critically Ill Patients

Not yet recruiting

• Conditions: Respiratory Failure
• Interventions: Other: Observetional

• Registration Number: NCT06395532
• Lead Sponsor: Ain Shams University

Brief Summary

The integrated pulmonary index (IPI) is a newly developed index for respiratory monitoring. However, there is limited evidence on its effectiveness and usefulness in critically ill patients. The purpose of this study is to evaluate the clinical relevance of the IPI as a predictor of respiratory compromise in critically ill patients.

Detailed Description

Recent developments aim to use multiple parameters to detect AREs. Application of smart algorithms that combine individual physiological variables into one index may increase the ability to detect a true adverse respiratory event while avoiding false alarms and limiting alarm fatigue.

An example of such a multiparameter index is the Integrated Pulmonary Index or IPI™, which integrates oxygen saturation (SpO2), respiratory rate (RR), end-tidal PCO2 (PETCO2) and heart rate (HR) into a single integer value of 1-10 that represents adequacy of respiratory condition of the patient using a fuzzy logic inference mathematical model; scores ≥ 8 points are within normal range and those ≤ 4 points suggest requirement of interventions.

The IPI algorithm summarizes the state of ventilation and oxygenation at the point in time. Previous studies reported that IPI correlated with respiratory physiological parameters of patients undergoing sedation for surgeries or for colonoscopy.

Up to our knowledge, the clinical relevance of the IPI as a predictor of respiratory compromise in critically ill patients has not been discussed before.

Study Timeline

• Status Verified: 2024-04
• Study First Submitted: 2024-04-23
• Study First Submitted QC: 2024-04-30
• Last Update Submitted: 2024-04-30
• Study First Posted: 2024-05-02
• Last Update Posted: 2024-05-02
• Study Start: 2024-05-15
• Primary Completion: 2024-11-16
• Study Completion: 2024-12-22

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• Critically ill patients aged 18 years or older of both genders admitted to the intensive care unit

Exclusion Criteria

• Age < 18 years' old
• Morbid obesity
• Mechanical ventilation
• Hemodynamic instability.
• Thoracotomy and cardiac surgery

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Non respiratory compromise (RC) group	Observetional	-
Respiratory compromise (RC) group	Observetional	-

Primary Outcome Measures

Name	Time	Method
Respiratory Failure	6 months	1. Hypoxia; 2. Hypercapnia

Secondary Outcome Measures

Name	Time	Method
Complications	6 months	1. The onset of Mechanical ventilation; 2. The Duration of Mechanical ventilation; 3. lCU length of stay; 4. Hospital length of stay 5-28 days mortality