Precision Immunology to Determine the Immune Response in Patients With COVID-19

• Conditions: COVID; SARS-CoV 2
• Interventions: Other: Blood draw

• Registration Number: NCT04360733
• Lead Sponsor: University of Bonn

Brief Summary

To better understand the immune response to SARS-CoV-2 infection, we devised a precision immunology approach to systematically study the immune function of different patient cohorts

Detailed Description

Not available

Study Timeline

• Study Start: 2020-04-20
• Study First Submitted: 2020-04-22
• Study First Submitted QC: 2020-04-22
• Study First Posted: 2020-04-24
• Status Verified: 2021-04
• Last Update Submitted: 2021-04-29
• Last Update Posted: 2021-05-05
• Primary Completion: 2022-04
• Study Completion: 2022-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• SARS-Cov2 positive PCR

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Exclusion Criteria

• pregnancy

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
severe Covid-19	Blood draw	Patients with confirmed SARS-CoV2 PCR and severe clinical symptoms with ICU admission
asymptomatic Covid-19	Blood draw	Patients with confirmed SARS-CoV2 PCR but no clinical symptoms
healthy controls	Blood draw	Persons with negative SARS-CoV2 PCR
symptomatic Covid-19	Blood draw	Patients with confirmed SARS-CoV2 PCR and light clinical symptoms

Primary Outcome Measures

Name	Time	Method
Immune response	4 weeks	Immune response of whole blood stimulation assay with various immune activators will be measured by FACS and multiplex Assay

Trial Locations

Locations (1)

University Hospital Bonn; 🇩🇪 Bonn, Germany