Trial of tyrosine and its effect on working memory in healthy elderly and young people
Completed
- Conditions
- plasma tyrosine levels, working memory performance
- Registration Number
- NL-OMON23338
- Lead Sponsor
- Wageningen University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 34
Inclusion Criteria
• Aged 18-35 years or aged 60-75 years
• Normal and stable weight (BMI 18.5-25 kg/m2 and weight 50-95 kg)
Exclusion Criteria
• Thyroid problems, such as hyperthyroidism, hypothyroidism, thyroid cancer
• Using medication that can interfere with tyrosine’s action; monoamine oxidase inhibitors and other antidepressants, sympathomimetic amines, and opioids
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Tyrosine plasma concentrations at T0, T90, T120, T150, T180, T210 and T240 at doses of 100 mg/kg body weight (elderly), 150/kg body weight mg (young and elderly) and 200 mg/kg body weight (elderly)
- Secondary Outcome Measures
Name Time Method Performance on the n-back task measured by accuracy (total number of hits) and reaction time (ms) on all doses