Development of a Non-invasive Assessment of Human Bone Quality Using Spatially Offset Raman Spectroscopy

Active, not recruiting

• Conditions: Osteoarthritis; Osteogenesis Imperfecta; Rickets / Osteomalacia; Osteoporosis; Bone Infection

• Registration Number: NCT02814591
• Lead Sponsor: University College, London

Brief Summary

In this study spatially offset Raman spectroscopy (SORS), which allows the collection of Raman spectra through turbid media, is being applied to collect Raman spectra of bone. The principal aim to find ways to use Raman spectroscopy to assess bone quality in vivo.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-10
• Study First Submitted: 2016-05-16
• Study First Submitted QC: 2016-06-22
• Study First Posted: 2016-06-28
• Status Verified: 2022-11
• Last Update Submitted: 2022-11-22
• Last Update Posted: 2022-11-23
• Primary Completion: 2024-06
• Study Completion: 2025-06

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 245

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
SORS Raman spectral fingerprint for bone disease types and changes over time	SORS Raman spectral features will be evaluated using a variety of multi-variate analytical tools e.g. BTEM at time zero and a repeat measure within a year.	Individual patient data will be pre-processed and extracted after patient participation visits. As cohorts are filled multivariate classification models will be built to validate disease discrimination and validation of the SORS technique.