Comparative evaluation of SRP with and without photobiomodulation on telomere length in patients with periodontitis- a clinical molecular study.
试验速览
- 阶段
- 1 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- to measure the length of telomere in human DNA before and after treatment
研究概览
简要总结
In this study,5ml of blood samples are drawn at baseline and on 21days.Patients are divided into two groups who shall undergo scaling and root planing while the patients of experimental group undergo photobiomodulation therapy along with scaling and root planing. Patients suffering from chronic generalized periodontitis often show characteristics of exaggerated inflammation that are associated with untimely reduction in the length of telomere in human DNA which is also co-related to aging and disorders such as alzhimers and diabetes. Photobiomodulation therapy reduces the inflammatort factors and may also stop the untimely reduction of DNA length. Thus proving to be beneficial to the patient in the long run.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 35.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients suffering from stage II Grade A periodontitis Possessing atleast 20 teeth Clinical Attachment Loss ≥ 3mm Age Range of 35-50 years Presence of local factors and bleeding on probing.
排除标准
- •Patients with systemic disease Patients who have undergone antimicrobial and/or antibiotic therapy in the last 3 months Lactating and pregnant mothers Smokers , alcoholic and / or any other recreational drug.
结局指标
主要结局
to measure the length of telomere in human DNA before and after treatment
时间窗: at baseline | at 21days
次要结局
- decrease in the loss of length of telomere in DNA(at baseline and at 21days)
研究者
Vinitha Saravanan
Sharavathi dental college and hospital, shimoga