NCT00202566已完成3 期
Evaluation of the Anti-anginal Efficacy and Safety of Oral Administration of Ivabradine Compared to Placebo on Top of Background Therapy With Atenolol in Patients With Stable Angina Pectoris. A Four-month Randomised Double-blind, Parallel Group International Multicentre Study.
适应症
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 750
- 试验地点
- 2
- 主要终点
- Improvement between baseline and end of treatment of the treadmill exercise tolerance test
研究概览
简要总结
To test whether ivabradine when given in combination with atenolol is able to improve the exercise tolerance of patients with stable angina pectoris
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chronic stable angina pectoris
- •Documented coronary artery disease
- •Previous treatment with atenolol or other beta-blocker agent
- •Exercise tolerance test positivity and stability
排除标准
- •Heart rate < 60 bpm
- •Congestive heart failure
结局指标
主要结局
Improvement between baseline and end of treatment of the treadmill exercise tolerance test
次要结局
- Rate pressure product
- Clinical evaluation
研究者
研究点 (2)
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