Myocardial Bridging in Obstructive Hypertrophic Cardiomyopathy

Completed

• Conditions: Myocardial Bridging; Obstructive Hypertrophic Cardiomyopathy; Atrial Fibrillation (AF)
• Interventions: Procedure: Coronary artery bypass grafting or unroofing

• Registration Number: NCT06598995
• Lead Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital

Brief Summary

This study investigated the impact of myocardial bridging (MB) and its characteristics on preoperative atrial fibrillation and survival in patients with obstructive hypertrophic cardiomyopathy (oHCM). We recruited 968 consecutive patients with oHCM who underwent myectomy at our institution between January 2015 and December 2019, including 144 patients with MB and 824 patients without MB. All patients received angiography before surgery. The diagnosis of preoperative atrial fibrillation was based on 12-lead electrocardiography, 24-hour Holter electrocardiography, or in-hospital electrocardiogram monitoring, which was extracted from patients' medical records. Surgical details and follow-up data were also collected.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-01-01
• Primary Completion: 2022-12-31
• Study Completion: 2022-12-31
• Status Verified: 2024-09
• Study First Submitted: 2024-09-12
• Study First Submitted QC: 2024-09-12
• Last Update Submitted: 2024-09-12
• Study First Posted: 2024-09-19
• Last Update Posted: 2024-09-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 968

Inclusion Criteria

I(i) age ≥ 18 years and (ii) diagnosis of oHCM based on clinical and echocardiographic evaluation.

Exclusion Criteria

(i) a history of heart surgery (ii) Patients who had coronary atherosclerosis or myocardial infraction; (iii) Patients who had no angiography records.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Obstructive hypertrophic cardiomyopathy who underwent septal myectomy	Coronary artery bypass grafting or unroofing	All patients underwent angiography and without other coronary artery disease.

Primary Outcome Measures

Name	Time	Method
All-cause death	One month after discharge	Any death occurred one month after discharge

Secondary Outcome Measures

Name	Time	Method
New-onset AF	One month after discharge.	Patients did not have AF before surgery, and AF occurred one month after discharge.
Composite endpoints	One month after discharge	Composite endpoints including all-cause death, new-onset AF, and readmission due to heart failure, stroke, and other cardiovascular events (such as myocardial infarction, arrhythmia).

Trial Locations

Locations (1)

Fuwai Hospital; 🇨🇳 Beijing, Please Select, China