Clinical-immunological Features of DNER Ataxia
- Conditions
- DNER Ataxia
- Registration Number
- NCT05225896
- Lead Sponsor
- Hospices Civils de Lyon
- Brief Summary
Using a retrospective cohort of 34 patients with DNER ataxia, we will characterize clinical presentation, tumor associations, and outcomes.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 34
Inclusion Criteria
- Patient > 18 years old
- Patient with neurological disorder
- Patient with DNER antibodies in sera or CSF
Exclusion Criteria
-
- No available clinical data
- Patient without DNER antibodies or neurological disorder
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Modified Rankin scale (mRS) 6 month after the beginning of study Residual neurological disability as assessed by the modified Rankin scale (mRS) score at last visit)
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie DNER ataxia pathogenesis and potential therapeutic targets?
How does DNER ataxia compare clinically to other autoimmune ataxia subtypes like anti-GAD or anti-CV2?
Are there specific autoantibody biomarkers that correlate with tumor associations in DNER ataxia patients?
What are the most effective management strategies for immune-related adverse events in DNER ataxia?
What immunotherapeutic approaches show promise for treating paraneoplastic ataxias like DNER?
Trial Locations
- Locations (1)
HCL Hôpital Neurologique / Groupement EST
🇫🇷Bron, France
HCL Hôpital Neurologique / Groupement EST🇫🇷Bron, France