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Clinical Trials/NCT01175746
NCT01175746CompletedNot Applicable

The Effect of Nicardipine on Kidney Function During Orthognathic Surgery Under Hypotensive Anesthesia

Yonsei University0 sites46 target enrollmentStarted: August 2010Last updated:
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Conditions
Interventions
Drugs

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
46
Primary Endpoint
Creatinine Clearance
Study OverviewStudy DesignEligibility CriteriaArms & InterventionsOutcomesInvestigatorsRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

Since nicardipine is known to protect kidney function, nicardipine infusion will result in better renal parameters measured in this study.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Prevention
Masking
Triple (Participant, Care Provider, Investigator)

Eligibility Criteria

Ages
20 Years to 40 Years (Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •healthy adult patients undergoing hypotensive anesthesia

Exclusion Criteria

  • •patients with any co-morbidity

Arms & Interventions

remifentanil

Active Comparator

Intervention: remifentanil (Drug)

nicardipine

Experimental

Intervention: Nicardipine (Drug)

Outcomes

Primary Outcomes

Creatinine Clearance

Time Frame: 2hr after the start of hypotensive anesthesia

Hypotensive anesthesia means that we maintain the mean blood pressure between 55 \& 65 mmHg during surgery to decrease the blood loss. The specific time point is exactly 2hr after we star to lower the blood pressure.

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

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