The Influence of Beetroot Juice on Racial Disparities in Vascular Health
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Changes in blood pressure
研究概览
简要总结
Black adults are 30% more likely to die from cardiovascular disease (CVD) compared to White adults, and more than half of this racial disparity in cardiovascular mortality may be attributed to the substantially greater prevalence of high blood pressure and vascular dysfunction in Black adults. Nitric oxide (NO) is a potent signaling molecule and key regular of vascular function that is suspected to be reduced in black individuals, but can be enriched by dietary nitrate (e.g., arugula, spinach, beets). The purpose of this study is to test the hypothesis that increasing NO bioavailability via nitrate-rich beetroot juice (BRJ) will lower blood pressure and improve vascular health in Black adults.
详细描述
The investigators long-term research goal is to investigate mechanisms accounting for the higher prevalence of CVD and high blood pressure in Black individuals, and identify effective preventive strategies. Nitric oxide (NO) is a gaseous molecule that plays an essential role in the regulation of vascular tone and blood pressure regulation. Some, but not all, studies have observed reduced NO bioavailability in Black individuals, which may contribute to racial disparities in vascular health. Dietary nitrate supplementation using beetroot juice (BRJ) is demonstrated to increase circulating NO, lower blood pressure and arterial stiffness, and improve blood pressure regulation in clinical populations and health individuals. The central hypothesis is that increasing NO bioavailability by nitrate-rich BRJ supplementation will lower blood pressure and improve vascular health in Black adults. The investigators acknowledge that racial differences are not entirely driven by ancestry, and thus will assess and account for sociocultural factors and health behaviors (i.e., sleep, physical activity, and nutrition) that may contribute to racial health disparities.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single (Investigator)
盲法说明
The experimenter will be blinded to what condition the participant is in, and all data analysis will be conducted blinded to the condition as well.
入排标准
- 年龄范围
- 18 Years 至 39 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Between 18-39 years of age
- •Body mass index (BMI) below 30 kg/m^2
- •Free from signs or symptoms of neurologic, cardiovascular (e.g., heart attack, stroke, heart failure, arrhythmia), metabolic, and/or renal disease
- •Have a blood pressure no lower than 90/50 mmHg
- •Are not currently smoking, using smokeless tobacco, nor smoked within the past 12 months
排除标准
- •Low blood pressure - less than 90/50 mmHg
- •History of cardiovascular disease
- •History of cancer
- •History of diabetes
- •History of kidney disease
- •Obesity (BMI > 30 kg/m^2)
- •Smoking or tobacco use
- •Current pregnancy
- •Nursing mothers
- •Communication barriers
结局指标
主要结局
Changes in blood pressure
时间窗: Baseline and two hours after beetroot juice ingestion, both conditions (experimental and control)
The investigators will use the SphygmoCor XCEL system to assess pulse wave analysis (PWA), which will provide brachial and aortic blood pressures (mmHg).
Changes in nitric oxide (NO) metabolites
时间窗: Baseline and two hours after beetroot juice ingestion, both conditions (experimental and control)
The investigators will use chemiluminescence detection to measure salivary and circulating NO metabolites (nitrate and nitrate).
Changes in blood pressure responses to stress
时间窗: Baseline and two hours after beetroot juice ingestion, both conditions (experimental and control)
The investigators will use the SphygmoCor XCEL system to assess pulse wave analysis (PWA) at rest and during handgrip exercise and after exercise during cuff occlusion.
Changes in arterial stiffness responses to stress
时间窗: Baseline and two hours after beetroot juice ingestion, both conditions (experimental and control)
The investigators will use the SphygmoCor XCEL system to assess pulse wave velocity (PWV) at rest and during handgrip exercise and after exercise during cuff occlusion.
Changes in arterial stiffness
时间窗: Baseline and two hours after beetroot juice ingestion, both conditions (experimental and control)
The investigators will use the SphygmoCor XCEL system to assess pulse wave velocity (PWV). A high-fidelity strain-gauge transducer is used to obtain the pressure waveform at the carotid pulse. Distances from the carotid artery sampling site to the femoral artery (upper leg instrumented with a thigh cuff for oscillometric sphygmomanometry), and from the carotid artery to the suprasternal notch will be recorded. PWV will be expressed as m/s.
次要结局
- Objective sleep duration(Baseline (pre-intervention))
- Economic determinants of health(Baseline (pre-intervention))
- Subjective sleep quality(Baseline (pre-intervention))
- Habitual dietary intake(Baseline (pre-intervention))
- Social determinants of health(Baseline (pre-intervention))
- Physical activity(Baseline (pre-intervention))
研究者
Gregory Grosicki
Assistant Professor
Georgia Southern University