studying to role of urinary neutrophil associated gelatinase biomarker as an early predictor of acute kidney injury in patients treated with antibiotic Colistin

Recruiting

Conditions: critically ill patients

Registration Number: CTRI/2018/02/012036

Lead Sponsor: All India Institute of Medical Sciences

Brief Summary: All patients with written informed consent falling under our inclusion criteria will be enrolled for our study. Detailed history and thorough physical examinations of the patient will be performed. All relevant investigation report will be noted. A note will be made of medication being taken by patient particularly nephrotoxic drugs if any. The indication (culture sensitivity, site of infection and microorganism isolated, or given empirically) would be noted. If a patient is having septic shock the requirement of vasopressors and duration shock state will be noted. Urine samples will be collected before and after administration of antibiotic at 2Hr, 24Hrs,2, 3, 5 and 7 and will be measured by using the FIA8000 quantitative immunoassay analyser .

Serum creatinine will be followed daily and urine output will be followed for detection of AKI. Creatinine value on the day of initiation of Colistin therapy will be considered as baseline creatinine. Acute kidney injury will be defined as per RIFLE criteria.

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: All

Target Recruitment: 50

Inclusion Criteria

all patients with age 18 years or more who are planned for colistin therapy.

Exclusion Criteria

1.Refusal of consent 2.History of chronic renal disease 3.Acute kidney injury features accordingg to RIFLE criteria 4.Recent contrast dye exposure(within 5 days).

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1.To study pattern of changes in urinary neutrophil gelatinase associated lipocalin after administration of colistin	At completion recruitment
2.To compare serum creatinine and urinary neutrophil gelatinase associated lipocalin levels for prediction of acute kidney injury in patients	At completion recruitment

Secondary Outcome Measures

Name	Time	Method
1.To identify factors associated for colistin induced Acute kidney injury	At completion of recruitment

Trial Locations

Locations (1): All India Institute of Medical Sciences
🇮🇳
Delhi, DELHI, India
All India Institute of Medical Sciences
🇮🇳Delhi, DELHI, India
Dr Anjan Trikha
Principal investigator
9810977901
anjantrikha@gmail.com