Identifying Challenges to Healthy Aging in Persons With HIV Age 50 and Older
Overview
- Phase
- N/A
- Intervention
- Customized activity plan
- Conditions
- HIV
- Sponsor
- Wake Forest University Health Sciences
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Physical Performance scores
- Status
- Recruiting
- Last Updated
- last month
Overview
Brief Summary
The primary objective of this study is to identify and characterize frailty and pre-frailty in persons age 50 and older living with human immunodeficiency virus (HIV) followed by the Atrium Health Wake Forest Baptist Infectious Diseases Specialty Clinics (IDSC).
Detailed Description
The study will implement electronic medical record-based screening for frailty (eFI), further characterize frailty using comprehensive geriatric screening, and offer a customized activity and nutrition plan to a subset of participants. Participation in phlebotomy for research biomarkers of aging is optional. The study also seeks to validate the electronic medical record embedded electronic frailty index (eFI) for the prediction of adverse outcomes in aging persons with HIV, characterize the symptoms of pre-frailty and frailty in persons followed in the IDSC, and assess the acceptability and efficacy of a customized activity and nutrition intervention targeting frailty. The study will also correlate research biomarkers of aging with aging symptoms in a subset of participants.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Person living with human immunodeficiency virus (HIV)
- •Age ≥50 years
- •Followed by the Atrium Health Wake Forest Baptist Infectious Diseases Specialty Clinic (IDSC)
- •Eligible for Ryan White Program
- •Able to provide informed consent
- •Pre-frail or frail by electronic frailty index (eFI)
Exclusion Criteria
- •Age \<50 years (study designed to characterize frailty in aging persons with HIV)
- •Unable to complete the required assessments or questionnaires
Arms & Interventions
Activity Intervention
Customized selection of exercise and other community and online activity options to improve activity.
Intervention: Customized activity plan
Nutrition Intervention
Development of a customized nutrition plan to address nutritional needs.
Intervention: Customized nutrition plan
Outcomes
Primary Outcomes
Physical Performance scores
Time Frame: Week 12
Change in physical performance battery scores - Minimum score 0 - Maximum score 12 - Higher scores indicate better lower extremity function
Secondary Outcomes
- Percentage of Adherence with Plan(Week 12)
- Quality of Life - 12-Item Short Form Health Survey (SF-12) Scores(Week 12)