The Physiological Effect of High Flow Oxygen Therapy

Not Applicable

• Conditions: High-flow Nasal Cannula; Acute Exacerbation of Chronic Obstructive Pulmonary Disease; Non-invasive Positive Pressure Ventilation
• Interventions: Device: HFNC; Device: NPPV

• Registration Number: NCT04212182
• Lead Sponsor: The First Affiliated Hospital of Guangzhou Medical University

Brief Summary

Although non-invasive positive pressure ventilation (NPPV) shows the good curative effect of treating the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), some patients do not tolerate NPPV or do not benefit from it. High-flow nasal cannula (HFNC) is well tolerated and may be used to patients with AECOPD who are intolerant to NPPV treatment. This study is to evaluate the physiological effect of HFNC and compare it with NPPV.

Detailed Description

Not available

Study Timeline

• Status Verified: 2019-12
• Study First Submitted: 2019-12-23
• Study First Submitted QC: 2019-12-24
• Study First Posted: 2019-12-26
• Last Update Submitted: 2019-12-26
• Study Start: 2019-12-27
• Last Update Posted: 2019-12-30
• Primary Completion: 2020-07-01
• Study Completion: 2020-07-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• AECOPD patients with acute hypercapnic respiratory failure

Exclusion Criteria

• other lung/pleural diseases or thoracic deformity
• severe heart failure (New York Heart Association class IV), severe dysrhythmia
• unstable angina, or malignant comorbidity
• obesity (BMI ≥ 35 kg/m²)
• severe obstructive sleep apnea syndrome

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
HFNC group	HFNC	AECOPD patients receive ventilation support via HFNC.
NPPV group	NPPV	AECOPD patients receive ventilation support via NPPV.

Primary Outcome Measures

Name	Time	Method
Neural respiratory drive	30 minutes	Neural respiratory drive is calculated by diaphragm electromyogram

Secondary Outcome Measures

Name	Time	Method
Work of breathing	30 minutes	Work of breathing is calculated by the transdiaphragmatic pressure
Transcutaneous CO2	30 minutes	Transcutaneous CO2 is a non-invasive method estimated the partial pressure of arterial blood CO2.

Trial Locations

Locations (1)

The First Affiliated Hospital of Guangzhou Medical University.; 🇨🇳 Guangzhou, Guangdong, China