To compare and evaluate the effectiveness of PRF with or without Osseograft in the treatment of intrabony defects in chronic periodontitis patients.

Not yet recruiting

Brief Summary: | | | |

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|Aims and objectives :

To compare and evaluate the effectiveness of Autologous Advanced PRF(A-PRF) with or without Bovine Derived Xenograft (Osseograft TM) in the treatment of intrabony defects in Chronic Periodontitis patients based on cliinical and radiographic parameters.

Materials and methods:

Fourty intrabony defects in which 40 patients were randomly divided into two different groups and were treated with group A (Ossegraft alone) and group B (Osseograft with A-PRF). Clinical parameters such as plaque index (PI), gingival index (GI), pocket probing depth (PPD), clinical attachment level (CAL) were assessed at baseline 1 month, 3 month and 6 month postoperatively; radiographic parameter such as percentage in bone fill (%BF) were calculated by using the computerized image analysis software.

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|Data collected will be entered into a computer and analyzed using the SPSS (Statistical Package for the Social Sciences) software. Results on continuous measurements will be presented on Mean Â± SD and results on categorical measurements will be presented in Number (%).

Chi square analysis will be used to find the significance of study parameters on categorical scale. Student t test (two tailed, independent) will be used to find the significance of study parameters on continuous scale within and between two groups (Intra and Inter group analysis) on metric parameters.

Recruitment & Eligibility

Inclusion Criteria

1.Patient in the age group between 30-60 years.
Patient who are non smokers and do not consume tobacco in any form.
Patients in good systemic health with no contraindications to periodontal surgery.
Patients having pocket depth greater than 5mm, intraosseous defects greater than 3mm with radiographic evidence of vertical or angular bone loss in the affected sites.
Involved teeth should be vital and asymptomatic.

Exclusion Criteria

1.) One-walled osseous defects.
1. Patients suffering from any systemic diseases judge to impair normal healing and immune-compromised patients.
1. Patients who had received any type of periodontal therapy for the past 6 months.
1. Patients taking immunosuppressant drugs like corticosteroids.
1. Patients with a known history of allergy to Doxycycline or Chlorhexidine or any other medicine used in the study.
1. Pregnant or lactating mothers.
1. Patients who were smokers or had tobacco in any other form.
1. Patients on anticoagulant therapy.

Primary Outcome Measures

Name	Time	Method
1. Plaque Index (P.I.) (Tureskey-Gilmore-Glickman Modification of Quigley Hein).	At Baseline \| After 1 month \| After 3 month \| After 6 month
2. Gingival Index (G.I.) (Loe and Silness, 1963)	At Baseline \| After 1 month \| After 3 month \| After 6 month
4. Clinical Attachment Level (CAL)	At Baseline \| After 1 month \| After 3 month \| After 6 month
3. Probing Pocket Depth (PPD)	At Baseline \| After 1 month \| After 3 month \| After 6 month

Secondary Outcome Measures

Name	Time	Method
The radiographic bone fill will be evaluated using Intraoral Periapical Radiographs of the surgical site	Baseline-at baseline. immediately after the surgery and 6 month post-surgery

Locations (1): Lishana Farnomi Ch Momin
🇮🇳
Mumbai, MAHARASHTRA, India
Lishana Farnomi Ch Momin
🇮🇳Mumbai, MAHARASHTRA, India
Lishana Farnomi Ch Momin
Principal investigator
8787681838
cheranlishana@gmail.com